Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
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Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST.
Nat Biotechnol. 2019 Apr 29.