GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells
Sewing S, Gubler M, Gérard R, Avignon B, Mueller Y, Braendli-Baiocco A, Odin M, Moisan A. Mol Ther Nucleic Acids. 2019 Mar 1;14:67-79. PubMed
Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice
Kim TW, Papagiannis CN, Zwick LS, Engelhardt JA, Hoffmaster CM, Post NM, Matson JE, Hsiao JA, Burel SA, Henry SP. Toxicol Pathol. 2018 Dec 25:192623318813143. PubMed
Role of Computationally Evaluated Target Specificity in the Hepatotoxicity of Gapmer Antisense Oligonucleotides
Kasuya T, Kugimiya A. Nucleic Acid Ther. 2018 Aug 10. PubMed
Investigation into the mechanism(s) that leads to platelet decreases in cynomolgus monkeys during administration of ISIS-104838, a 2′-MOE-modified antisense oligonucleotide
Narayanan PK, Shen L, Curtis BR, Bourdon M, Nolan JP, Zhou F, Christian B, Gupta S, Schaubhut JL, Greenlee S, Hoffmaster C, Burel S, Witztum JL, Engelhardt JA, Henry SP. Toxicol Sci. 2018 May 29. PubMed
Chronic Toxicity Assessment of 2′-O-Methoxyethyl Antisense Oligonucleotides in Mice
Zanardi TA, Kim TW, Shen L, Serota D, Papagiannis C, Park SY, Kim Y, Henry SP. Nucleic Acid Ther. 2018 Apr 30. PubMed
Intracerebroventricular Administration of a 2′-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain
Toonen LJA, Casaca-Carreira J, Pellisé-Tintoré M, Mei H, Temel Y, Jahanshahi A, van Roon-Mom WMC. Nucleic Acid Ther. 2018 Apr;28(2):63-73. PubMed
A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides
Dieckmann A, Hagedorn PH, Burki Y, Brügmann C, Berrera M, Ebeling M, Singer T, Schuler F. MolTher Nucleic Acids. 2018 Mar 2;10:45-54. PubMed
RNA-Seq Analysis of an Antisense Sequence Optimized for Exon Skipping in Duchenne Patients Reveals No Off-Target Effect
Domenger C, Allais M, François V, Léger A, Lecomte E, Montus M, Servais L, Voit T, Moullier P, Audic Y, Le Guiner C. MolTher Nucleic Acids. 2018 Mar 2;10:277-291. PubMed
2′-O-(2-methoxyethyl) nucleosides are not phosphorylated or incorporated into the genome of Human Lymphoblastoid TK6 Cells
Saleh AF, Bachman M, Priestley CC, Gooderham NJ, Andersson P, Henry SP, Edmunds N, Fellows MD. Toxicol Sci. 2018 Jan 9. PubMed
Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia
Sewing S, Roth AB, Winter M, Dieckmann A, Bertinetti-Lapatki C, Tessier Y, McGinnis C, Huber S, Koller E, Ploix C, Reed JC, Singer T, Rothfuss A. PLoS One. 2017 Nov 6;12(11):e0187574. PubMed
