AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington’s Disease Minipig Model
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Ribosomal Protein S3 Gene Silencing Protects Against Cigarette Smoke-Induced Acute Lung Injury
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MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct
Jain R, Frederick JP, Huang EY, Burke KE, Mauger DM, Andrianova EA, Farlow SJ, Siddiqui S, Pimentel J, Cheung-Ong K, McKinney KM, Köhrer C, Moore MJ, Chakraborty T. Nucleic Acid Ther. 2018 Aug 8. PubMed
MicroRNA-92a antagonism attenuates lipopolysaccharide (LPS)-induced pulmonary inflammation and injury in mice through suppressing the PTEN/AKT/NF-κB signaling pathway
Fu L, Zhu P, Qi S, Li C, Zhao K. Biomed Pharmacother. 2018 Aug 20;107:703-711. PubMed
MicroRNA-30c-5p modulates neuropathic pain in rodents
Tramullas M, FrancĂ©s R, de la Fuente R, Velategui S, CarcelĂ©n M, GarcĂa R, Llorca J, HurlĂ© MA. Sci Transl Med. 2018 Aug 8;10(453). PubMed
Up-regulated miR-192-5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2-mediated TGF-β1 signaling pathway
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Intrathecal Injection of miR-133b-3p or miR-143-3p Prevents the Development of Persistent Cold and Mechanical Allodynia Following a Peripheral Nerve Injury in Rats
Norcini M, Choi D, Lu H, Cano M, Piskoun B, Hurtado A, Sideris A, Blanck TJJ, Recio-Pinto E. Neuroscience. 2018 Aug 21;386:223-239. PubMed
OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers
Monroig-Bosque PDC, Shah MY, Fu X, Fuentes-Mattei E, Ling H, Ivan C, Nouraee N, Huang B, Chen L, Pileczki V, Redis RS, Jung EJ, Zhang X, Lehrer M, Nagvekar R, Mafra ACP, Monroig-Bosque MDM, Irimie A, Rivera C, Dan Dumitru C, Berindan-Neagoe I, Nikonowicz EP, ...
microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-associated Protein 1 to Suppress Hepatocarcinogenesis
Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A, Buendia MA, Vucur M, Heikenwalder M, Zucman-Rossi J, Zender ...
MicroRNA-148b Targets the TGF-β Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing
Miscianinov V, Martello A, Rose L, Parish E, Cathcart B, Mitić T, Gray GA, Meloni M, Al Haj Zen A, Caporali A. Mol Ther. 2018 Aug 1;26(8):1996-2007. PubMed