Muthiah (Mano) Manoharan, PhD

Honorary Member


Senior Vice President of Innovation Chemistry, Distinguished Research Scientist
Alnylam Pharmaceuticals

Dr. Muthiah (Mano) Manoharan serves as Senior Vice President of Innovation Chemistry and a Distinguished Research Scientist, and a member of the Scientific Advisory Board at Alnylam Pharmaceuticals, Cambridge, Massachusetts, USA.  Dr. Manoharan joined Alnylam in 2003. He built the chemistry group at Alnylam and pioneered the discovery of GalNAc-conjugated siRNAs for RNA interference-based human therapeutics. Dr. Manoharan has had a distinguished career as a world-leading chemist in the areas of oligonucleotide chemical modifications, conjugation chemistry, and delivery platforms (lipid nanoparticles, polymer conjugates, and complex-forming strategies). He is an author of more than 200 publications (nearly 39,000 citations with an h-index of 88 and an i10-index of 340) and over 400 abstracts, as well as the inventor of over 225 issued U.S. patents.  He is  the recipient of the M. L. Wolfrom award of the American Chemical Society Carbohydrate Chemistry (CARB) Division in 2007 and the Life Time Achievement Award by the Oligonucleotide Therapeutics Society (OTS) in 2019.