OTS members are on the forefront of efforts around the world to provide critical diagnostics and to develop therapeutics that can attack SARS-CoV-2 in cells, or even prevent infection. This webinar is a summary of some of the work that OTS members shared with our community through our recent questionnaire to our members. The approaches reviewed span a wide range of oligonucleotide platforms, including diagnostics, siRNA, antisense, aptamers, activating RNA, vaccines (including protein +CpG oligo, mRNA, DNA, and viral vector approaches), and innate immune activation by CpG DNA to prevent infection. A number of challenges that need to be addressed in order for the approaches to succeed also are considered. Learn about how the technologies that our community has developed can stop the pandemic!