Prof. Tuschl trained as a nucleoside and RNA chemist/biochemist and started his laboratory in 1999 by elucidating the mechanism of RNAi using Drosophila and human biochemical systems. Currently, the Tuschl laboratory studies RNA in the context of basic biology and human disease, defining interaction networks involving coding and non-coding RNAs and RNA-binding proteins (RBPs).
The lab explores mechanisms of RNA biogenesis, posttranscriptional gene regulation, and nucleic acid sensing. The lab applies expertise in RNA, to characterize complex normal and disease conditions on a tissue and single-cell level, as well as to evaluate the potential of extracellular RNAs as biomarkers in biofluids. The lab is curating the human transcriptome, using software and a database that we have developed to manage a vast collection of primary RNAseq data from diverse sources and methodologies.
Furthermore, to supplement routine tissue morphometric diagnostic analysis and immunohistochemistry, the lab develops improved quantitative multicolor RNA fluorescence in situ hybridization approaches.