Society News2021-08-27T10:57:04+00:00
5September, 2023

Fanzor: A Programmable RNA-Guided System In Eukaryotes Similar to CRISPR

September 5th, 2023|Categories: Featured Perspectives On Current Science|

Researchers have uncovered the first programmable RNA-guided system in eukaryotes that could be even more precise than CRISPR gene-editing. The discovery — led by Feng Zhang at the McGovern Institute for Brain Research at MIT and the Broad Institute of MIT and Harvard — demonstrates that DNA-modifying proteins exist across all kingdoms of life (1). In a recently published study ...

25August, 2023

RNAi: The Persistence of a Few Leads to Success

August 25th, 2023|Categories: Featured Perspectives On Current Science|

On August 10, 2018, the U.S. Food and Drug Administration (FDA) approved the first RNAi therapy. The approval marked a significant milestone not just for the drug but the entire field of  RNA interference (RNAi). The success of the technology was never guaranteed, and a tumultuous period where Big Pharma companies started selling off their RNAi assets heralded what ...

21August, 2023

From Failure to Meet the Clinical Endpoint to U.S. Food and Drug Administration Approval: 15th Antisense Oligonucleotide Therapy Approved Qalsody (Tofersen) for Treatment of SOD1 Mutated Amyotrophic Lateral Sclerosis

August 21st, 2023|Categories: Featured Perspectives On Current Science|

On April 25 2023, the U.S. Food and Drug Administration (FDA) granted accelerated approval to tofersen (trade name Qalsody) for the treatment of Superoxide Dismutase 1 (SOD1) associated amyotrophic lateral sclerosis (ALS) [1]. The clinical trial failed to meet its primary endpoint; however, approval was granted based on a biomarker response: reduced plasma levels of neurofilament light protein [2]. ...

2August, 2023

Investigating the Biology and Potential of CircRNA

August 2nd, 2023|Categories: Featured Perspectives On Current Science, Perspectives on Current Science|

In the past few years, mRNA has become a mainstream word with the swift creation of mRNA vaccines to treat SARS-CoV-2. This new technology was already in development, placing it in the perfect position to meet an urgent global need. Yet, there are still challenges to be met to further improve mRNA vaccines and other mRNA therapeutics. Another RNA ...

10July, 2023

Hydrogels and Nucleic Acids – An Innovative Combination

July 10th, 2023|Categories: Featured Perspectives On Current Science, Perspectives on Current Science|

An incredible amount of time, effort, and money have gone into finding increasingly better ways to safely and effectively deliver nucleic acid based therapeutics. Many solutions have been developed that do indeed provide safe and effective delivery, and we have had many occasions to celebrate the approval of life-saving drugs in recent years. However, new solutions are always valuable. The ...

29June, 2023

The Oligonucleotide Therapeutics Society is Pleased to Announce the 2023 Annual Meeting in Barcelona, Spain

June 29th, 2023|Categories: Featured Perspectives On Current Science, Perspectives on Current Science|

The Oligonucleotide Therapeutics Society (OTS) is excited to bring together those in the field of oligonucleotide therapeutics for its 19th Annual Oligo Meeting. Anyone interested in oligonucleotide therapeutics is welcome to join the event, which will be held virtually and in person on Oct. 22-25, 2023, in Barcelona, Spain. OTS is an open, nonprofit forum that fosters academic and ...

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