Shruti Sasaki is a postdoctoral fellow at Ionis Pharmaceuticals. Her primary research interests are mechanisms of translational control and how they contribute to human disease. Shruti received her B.S. in Chemical Biology at the University of California, Berkeley, where she worked collaboratively in Jennifer Doudna’s lab to determine the structure and function of the internal ribosome entry site (IRES) that drives translation of the Hepatitis C viral RNA.
She completed her Ph.D. in Biochemistry at the University of Wisconsin–Madison under the mentorship of Marv Wickens. Her graduate work focused on elucidating a novel mechanism of translation repression utilized by miRNAs and RNA-binding proteins, involving the role of protein interactions with the CCR4-NOT complex.
At Ionis, Shruti is working toward potential therapies for Cystic Fibrosis by using antisense oligonucleotide-mediated upregulation of protein expression. Through leadership roles she held in graduate school, Shruti developed a strong interest in increasing awareness of career advancement opportunities for junior scientists. She is excited about her role as a trainee representative, and she looks forward to helping to organize events and establish mechanisms to support the growing OTS junior scientist community.