Recent Articles2022-03-14T07:39:44+00:00
29May, 2021

mRNA Is Capable of Providing Solutions Far Beyond Vaccines

Categories: Perspectives on Current Science|

When the FDA issued emergency use authorization for Pfizer-BioNTech and Moderna’s COVID-19 vaccines, mRNA instantly became a household word. Many people believed that this new technology had sprung up out of nowhere in less than a year. What they did not know is that it had been in development ...

20May, 2021

Oligonucleotides Provide Hope for the Treatment of Duchenne Muscular Dystrophy

Categories: Perspectives on Current Science|

Imagine if your muscles began weakening for no apparent reason. Then, after an ongoing search for a diagnosis, you learn that you have a disease in which your muscles would progressively waste away and become weaker until you would no longer be able to walk. Ultimately, the disease would ...

14April, 2021

Phase III Trial of ASO Therapy for the Treatment of Huntington’s Disease Halted

Categories: Perspectives on Current Science|

Recently, people who have been impacted by Huntington’s disease, their families, and the OTS community were disappointed to learn that the GENERATION HD1 Phase III study of Tominersen was halted based on the recommendation of an unblinded Independent Data Monitoring Committee. Although not based on emergent safety concerns, the ...

30March, 2021

siRNA: From a Powerful Research Tool to Potent Therapeutic Modality

Categories: Perspectives on Current Science|

Earlier this year we celebrated the 20th Anniversary of RNA Interference in Mammalian Cells. In this article, we are going to discuss small interfering RNA (siRNA), a key mechanism that induces gene silencing in the RNAi pathway. siRNAs are highly specific, making them a powerful tool to suppress the ...

16March, 2021

The Astonishing History, Controversies, and Game-Changing Uses of CRISPR

Categories: Perspectives on Current Science|

Many of us view CRISPR as an incredibly useful tool. It is even referred to as genetic scissors because CRISPR allows scientists to edit the genes (the DNA) of organisms, from the smallest cells to an entire mammal. Because of its revolutionary impact on life sciences, the discovery of ...

25February, 2021

The Emerging Era of N-of-1 Drugs for Ultra-Rare Genetic Diseases

Categories: Perspectives on Current Science|

Imagine if a medication or therapy could be created to treat just one individual with an ultra-rare disease. There are nearly 7,000 known rare diseases (1) and many are debilitating and ultimately fatal. In the U.S., a disease is considered rare when it affects as many as 200,000 people. ...

11February, 2021

Facts about COVID-19 mRNA Vaccines and the Decades of Research That Went into Creating Them

Categories: Perspectives on Current Science|

Posted: February 11, 2021 | Updated: October 8, 2021 Despite the global threat of COVID-19, mRNA vaccines, which are highly effective at preventing COVID-19 illness and have passed rigorous safety standards, have been met with skepticism by many people. This suspicion is due in part to misconceptions and misinformation ...

25January, 2021

20th Anniversary of RNA Interference in Mammalian Cells

Categories: Perspectives on Current Science|

The groundbreaking discovery of RNA interference by Craig Mello and Andrew Fire was swiftly followed by the discovery of RNAi as a gene-silencing mechanism in mammalian cells. Since these breakthroughs, members of our community have devoted their lives to building on these exciting discoveries, and together we are producing ...

12January, 2021

Oligonucleotides and the OTS Community Provide Excellent Solutions to the COVID-19 Pandemic

Categories: Perspectives on Current Science|

Oligonucleotide therapies are relatively new in the field of medicine, but they have allowed us to make astounding progress in the fight against COVID-19. Rather than simply repurposing existing drugs or spending years to develop new drugs and vaccines, oligo therapies are quickly providing solutions to this global health ...

mRNA Is Capable of Providing Solutions Far Beyond Vaccines

May 29th, 2021|Categories: Perspectives on Current Science|

When the FDA issued emergency use authorization for Pfizer-BioNTech and Moderna’s COVID-19 vaccines, mRNA instantly became a household word. Many people believed that this new technology had sprung up ...

Comments Off on mRNA Is Capable of Providing Solutions Far Beyond Vaccines

Oligonucleotides Provide Hope for the Treatment of Duchenne Muscular Dystrophy

May 20th, 2021|Categories: Perspectives on Current Science|

Imagine if your muscles began weakening for no apparent reason. Then, after an ongoing search for a diagnosis, you learn that you have a disease in which your muscles ...

Comments Off on Oligonucleotides Provide Hope for the Treatment of Duchenne Muscular Dystrophy

Phase III Trial of ASO Therapy for the Treatment of Huntington’s Disease Halted

April 14th, 2021|Categories: Perspectives on Current Science|

Recently, people who have been impacted by Huntington’s disease, their families, and the OTS community were disappointed to learn that the GENERATION HD1 Phase III study of Tominersen was ...

Comments Off on Phase III Trial of ASO Therapy for the Treatment of Huntington’s Disease Halted

siRNA: From a Powerful Research Tool to Potent Therapeutic Modality

March 30th, 2021|Categories: Perspectives on Current Science|

Earlier this year we celebrated the 20th Anniversary of RNA Interference in Mammalian Cells. In this article, we are going to discuss small interfering RNA (siRNA), a key mechanism ...

Comments Off on siRNA: From a Powerful Research Tool to Potent Therapeutic Modality

Facts about COVID-19 mRNA Vaccines and the Decades of Research That Went into Creating Them

February 11th, 2021|Categories: Perspectives on Current Science|

Posted: February 11, 2021 | Updated: October 8, 2021 Despite the global threat of COVID-19, mRNA vaccines, which are highly effective at preventing COVID-19 illness and have passed rigorous ...

Comments Off on Facts about COVID-19 mRNA Vaccines and the Decades of Research That Went into Creating Them

Oligonucleotides and the OTS Community Provide Excellent Solutions to the COVID-19 Pandemic

January 12th, 2021|Categories: Perspectives on Current Science|

Oligonucleotide therapies are relatively new in the field of medicine, but they have allowed us to make astounding progress in the fight against COVID-19. Rather than simply repurposing existing ...

Comments Off on Oligonucleotides and the OTS Community Provide Excellent Solutions to the COVID-19 Pandemic

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