Categories: Upcoming WebinarsPublished On: January 27th, 2025

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Date: March 13, 2025
Time: 11-12pm EST

Title: Enhancing Aptamer Diversity for Targeted Therapeutics Using DNA-Encoded Libraries

Presentation Description:

Aptamers are promising precision tools for targeting disease-causing proteins, but their clinical application is hindered by limited binding affinity, poor stability, and rapid degradation. To overcome these challenges, chemically modified components such as lipids, peptides, and sugars can be incorporated at specific nucleotide positions to enhance their stability, specificity, and binding strength. By employing a DNA “barcode” system, it is possible to generate a large library of 300,000 aptamers and efficiently identify high-affinity candidates for disease-related proteins, particularly those involved in cancer progression. This approach holds great potential for advancing precision therapies.

Speaker:

Chris Saab, PhD Candidate
McGill University