Genome editing allows targeted, permanent changes to be made in the DNA. Oligonucleotides, by contrast, target gene transcripts, which have a high turnover. As such, repeated treatment is required for oligonucleotide therapeutics, ranging from weekly to every 6 months, depending on the target transcript and target tissue.
Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents. Frenck et al. N Engl J Med. 2021 May 27; DOI: 10.1056/NEJMoa2107456
While waiting in line to receive my second Moderna Covid-19 mRNA vaccine, I read the recent paper on evaluating the safety, immunogenicity, and efficacy of the Pfizer/Biontech Covid-19 mRNA vaccine in adolescents.