Senior Research Scientist – Synthetic chemistry in Oligonucleotide field

Full time @AstraZeneca in Life Sciences
  • Moelndal, Vaestra Goetaland, Sweden View on Map
  • Post Date : February 17, 2023
  • Apply Before : March 12, 2023
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Job Detail

  • Job ID 86878
  • Job Type Full-time
  • Qualifications Ph.D.

Job Description

Are you a passionate scientist with expertise in synthetic chemistry and have a great interest in the development of Oligonucleotide Therapeutics? Do you wish to join a growing team where you will have the opportunity to further exploit our drug discovery platforms? If yes, we might have the position for you!

Welcome to join the great Oligonucleotide Chemistry team as a motivated Senior Research Scientist at AstraZeneca in Gothenburg, Sweden. In this position, you will play an important part in our Oligonucleotide Discovery Department which is part of the broader Discovery Sciences R&D organization.

AstraZeneca is committed to the development of next generation innovative medicines and is focused on expanding the use of oligonucleotides and molecular conjugates thereof, in the treatment of diseases across therapy areas. As an specialist and member of the Oligonucleotide Medicinal Chemistry team you will have a key role to influence the strategy as well as to develop and lead the science in the field to expand the use of therapeutic oligonucleotides in drug projects within AstraZeneca.

Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment.

What you will do:
This role is a synthesis specialist role with the aim to develop novel oligonucleotide chemistry building blocks, oligonucleotides and oligo conjugates and thereby supporting the AstraZeneca pipeline. The Senior Research Scientist works alongside other chemists in the team to contribute to drug projects but should also be comfortable in supervising and mentoring more junior colleagues.

In the position you will also propose experimental strategies and have the possibility to be creative in solving a wide range of synthetic challenges. Plan, prioritize and perform own work and actively collaborate with the project team by driving problem solving using literature and own knowledge. Support oligonucleotide projects to ensure high scientific standards and quality of compounds to meet project objectives. Build strong collaborative relationships within the team and in projects to ensure the smooth running of projects.

We rely on you to have recognized synthesis expertise and experience. Knowledge within the oligonucleotide chemistry field is considered a plus including synthesis and purification of high quality building blocks and oligo compounds by applying innovative technologies and methodologies to support project progression according to agreed timelines. The SRS should also be able to apply analytical sciences, troubleshoot challenges and make a significant contribution to the practical delivery of project compounds.

Essentials for this role:

  • Candidate should have a PhD in Organic Chemistry, post-doc is a plus.
  • Detailed knowledge of synthetic chemistry related to oligonucleotides, oligo building blocks and/or synthesis of advanced organic molecules. Knowledge in the area of oligonucleotide therapeutics, design and data analysis is a plus.
  • Ability to design and complete experiments independently.
  • Evidence of experimental impact by either peer-reviewed publications or external presentations.

We believe that our new team member will share our passion for driving scientific questions and is a scientifically critical individual with curiosity to explore. You should have a positive, goal oriented and problem-solving attitude. Ability to enjoy working and effectively operate in a multi-disciplinary research environment is a must. We also believe that you enjoy teamwork, have a collaborative nature and is an encouraging colleague to all.

Why AstraZeneca?
With more than 2,800 employees from over 70 different countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life. Our belief powers us to push the boundaries. As we improve success rates, we keep moving forward. Celebrating both successes and failures along the way.

So, what’s next? If this sound like the place and position for you – welcome to apply today!

We look forward to your application and getting to know you better, but please remember to send it to us no later than March 12th, 2023.

For more information about the position please contact Anders Dahlén at +46 31 706 4842 or

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