Scientist

Full time @Confluence Therapeutics in Life Sciences
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Job Detail

  • Job ID 83986
  • Job Type Full-time
  • Experience 2 Years
  • Industry Life Science
  • Qualifications Ph.D.

Job Description

Confluence Therapeutics is developing a novel platform of oligonucleotide therapeutics for diseases of the CNS and other therapeutic areas with significant unmet need. Our mission requires strategic thinking, nimbleness and deep expertise in several areas including neurobiology, RNA biology, oligonucleotide chemistry, in vitro and in vivo pharmacology. This new startup company is recruiting for talented, experienced, and passionate individuals who are looking to meaningfully contribute to the creation of new medicines. Confluence is a fast-paced, dynamic environment where the teammates will have broad exposure to many aspects of drug development. The company is backed by top blue chip venture investors, Venrock and Osage University Partners. We are rapidly building the Company and are looking for scientists to join us on this mission.

 

Confluence Therapeutics, located in South San Francisco, CA, is seeking an exceptional individual to join our team as a Scientist. In this laboratory-based position, the successful candidate will develop cellular assays, support the development of PD biomarkers, lead bioinformatics activities to support all programs, and generate data to identify the optimal oligonucleotide candidate for the lead program. If interested, please send your CV to Yan Poon at ypoon@confluencetx.com.

 

Key Responsibilities:

  • Design and execute in vitro experiments, analyze and interpret data to support discovery and preclinical development using a variety of readouts
  • Work with a diverse and cross-functional team of wet-lab scientists and external collaborators to generate key datasets that are critical for the declaration of development candidates
  • Develop and validate PD biomarkers that can be applied both preclinically and clinically
  • Build and conduct validation assays to demonstrate proof-of-concept of a new platform in therapeutically relevant areas
  • Maintain accurate and complete documentation of experimental results for study reports and regulatory submissions

 

Qualifications:

  • D. in RNA biology, neurobiology, or oligonucleotide chemistry (or a relevant scientific discipline) with 2+ years experience in biotechnology and/or drug development
  • Experience in bioinformatics for genomics, NGS, and a programming language (R, Python) is preferred
  • Extensive knowledge of and experience with pharmacology, PK-PD relationships, and interrogating molecular target engagement and downstream physiological endpoints
  • Familiarity with cellular assays (g., cell lines, primary cells, neurons, IPSCs)
  • Hands-on experience with molecular biology including qPCR, western blots, and plate-based immunoassays (g., ELISAs, MSD, Luminex)
  • Creativity and the ability to work and debate constructively within an interdisciplinary team to achieve technical success and corporate milestones
  • Strong experience in statistical analysis software (g., Graphpad Prism)
  • Familiarity with data capture, analysis, and visualization within an Electronic Lab Notebook
  • Results-oriented individual with exceptional organization, attention to detail, scientific versatility, flexibility, critical thinking, and communication skills
  • Experience in a managerial role is preferred

Required skills

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