Scientist II, Discovery Chemistry

Full time @Sarepta Therapeutics in Life Sciences
  • Massachusetts, United States, 215 First Street, Cambridge MA, USA, 02142 View on Map
  • Post Date : May 4, 2022
  • Apply Before : June 6, 2022
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Job Detail

  • Job ID 84362
  • Job Type Full-time
  • Industry Life Science

Job Description

The RNA Research group at Sarepta Therapeutics is seeking a talented, motivated, and experienced scientist to join the dynamic and fast-paced chemistry team located in Cambridge, MA. The successful candidate will work on our PMO oligonucleotide platform and discovery research on improved delivery of oligonucleotides as well as manage collaborations and CROs as needed. This position will work closely with Discovery Biology, Translational Sciences, Business Development and Legal teams to implement new drug discovery programs and advance next generation of RNA therapeutics

The Position:

The RNA Research group at Sarepta Therapeutics is seeking a talented, motivated, and experienced scientist to join the dynamic and fast-paced chemistry team located in Cambridge, MA. The successful candidate will work on our PMO oligonucleotide platform and discovery research on improved delivery of oligonucleotides as well as manage collaborations and CROs as needed. This position will work closely with Discovery Biology, Translational Sciences, Business Development and Legal teams to implement new drug discovery programs and advance next generation of RNA therapeutics

Primary Responsibilities Include:

  • Design and conduct novel oligonucleotide conjugates synthesis, purification, and characterization; Apply state-of-the-art delivery methods to achieve in vivo proof of concept; Develop efficient and scalable synthetic methods and routes.
  • Develop and utilize innovative synthetic, medicinal chemistry and/or chemical biology problem solving skills coupled with analysis of diverse data sets to build structure-activity relationships
  • Act as key member of a multidisciplinary RNA research team, assisting with development of project strategy, and analysis and communication of complex data.
  • Serves as an in-house oligonucleotide and delivery chemistry expert.
  • Drive the writing of technical reports to support patent applications and manuscript preparations.
  • Coordinate and manage collaborations and CRO operations to ensure deliverables meet project needs
  • Organize workstreams and complete individual and team objectives to maintain project timelines.
  • Supervise and mentor junior staff

Desired Education and Skills: 

  • The ideal candidate will have a PhD in organic chemistry, biochemistry, or related fields with 4+ years of relevant post-doctoral or industry experience; or M.S. with 8+ years of experience
  • Strong experience in organic chemistry and multi-step organic synthesis is a must; Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is essential for this role
  • Previous experience in the design, chemical optimization, and formulation/delivery of peptides and/or oligonucleotide therapeutics is highly desirable
  • Experience with using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase (HPLC/UPLC), MALDI-TOF and Liquid Chromatography Mass Spectrometry (LC-MS) is a plus.
  • Track record with the ability to execute multiple concurrent research projects within a cross-functional team environment

Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary

This position requires work on site at one of Sarepta’s facilities in the United States. Candidates should be aware that Sarepta currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 in order to work on site. Newly hired employees must be vaccinated prior to their employment start date. Sarepta is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.

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