Research Scientist – Chemistry Synthesis and Scale Up

Full time @NATA in Life Sciences
  • England, United Kingdom, United Kingdom View on Map
  • Post Date : February 22, 2023
  • Apply Before : March 12, 2023
  • View(s) 121
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Job Detail

  • Job ID 86904

Job Description

NATA Research Scientist – Chemistry Synthesis and Scale Up

Band 4 £32,005 – £35,143 per annum

Full time, Permanent

Harwell Campus, Oxfordshire

The closing date for applications is 12-Mar-2023

About us

The Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), has invested £30m over 4 years through the Strategic Priorities Fund to establish a nucleic acid therapy accelerator (NATA) that will support state-of-the-art interdisciplinary research to solve critical issues in nucleic acid drug development, through focused NATA research challenges and a NATA infrastructure hub.

The NATA ( will focus on building internal chemistry, biology and operational capabilities at the hub while catalysing collaborative R&D activity to tackle significant barriers facing oligonucleotide therapy manufacturing and delivery. This investment will support capacity building in terms of equipment, upskilling and domain expertise that will be essential in developing critical mass to catalyse and de-risk the development of next-generation nucleic acid therapeutics.

About the Roles

We have an exciting and interesting opportunity for a Research Scientist to join the Oligonucleotide Synthesis and Scale Up team, developing new therapeutic oligonucleotides for various translational and collaborative projects. The Research Scientist will play a key role in designing, synthesising, and evaluating existing and new chemical modifications for nucleic acid therapeutics.

Key Responsibilities include:·

  • Designing, synthesising and analysing oligonucleotides.
  • Designing and implementing processes and workflows for oligonucleotide production.
  • Learning and implementing new techniques/methods for oligonucleotide production.
  • Perform HPLC purification of oligonucleotides and related biomolecules.
  • Managing chemistry laboratory resources efficiently and troubleshooting procedures.
  • Conducting quality control and preparing data sheets.
  • Recognise opportunities for the creation of intellectual property and cooperate in patent protection and exploitation.
  • Keeping excellent scientific records and implementing databases.

About YouYou will have:

  • A degree in a chemistry-related field with relevant academic/industry experience and have a proven track record of oligonucleotide design, synthesis and analysis.
  • Experience in HPLC purification systems and LC-MS analysis of nucleic acids.
  • Knowledge of organic chemistry and/or nucleic acid chemistry.
  • Experience in establishing, optimising and adopting operating procedures.
  • Experience in data analysis, interpretation and critical thinking.

For the full job description, please click apply.

Benefits:Choosing to come to work at the MRC (part of UK Research and Innovation (UKRI)) means that you will have access to a whole host of benefits, from a defined-benefit pension scheme and excellent holiday entitlement, to access to employee shopping/travel discounts and a salary sacrifice cycle to work scheme. In addition, you will have the opportunity to contribute to the work of a world-class medical research organisation.

How to Apply:Click apply for full details and to apply to submit an application. Your cover letter should clearly outline how you fulfil the criteria listed in the personal specification and your motivation for applying for this role.

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