Principal Scientific Researcher

Full time @Genentech in Life Sciences
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Job Detail

  • Job ID 84688

Job Description

The Position

We are seeking a talented Principal Scientific Researcher to join the Department of Protein Chemistry – Large Molecule Drug Discovery at Genentech. We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group. The candidate must have hands on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry. Experience in delivery of oligonucleotide therapeutics, large molecule drug discovery, or bioconjugation would be preferred.

The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology and oncology, to help build a comprehensive therapeutic discovery strategy. The position requires effective participation in multidisciplinary teams with biology, in vivo pharmacology, assay development and safety assessment scientists. The candidate will be expected to support pipeline projects and present at team meetings.


The qualified individual will possess a BS, MS or Ph.D. in Organic Chemistry or related discipline and possess a record of accomplishments and publication. Candidates should have demonstrated expertise in nucleic acid chemistry and oligonucleotide synthesis with a proven track record of publications in this field. Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bioconjugation is desirable but not necessary.  Excellent communication and interpersonal skills are essential and will be evaluated during the interview process. The ideal candidate will also be highly motivated and have strong problem-solving, analytical, communication and organizational skills.

Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer, and other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset and are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the “Apply online” button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

Roche is an equal opportunity employer.

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