Head of Oligo Platform Biology

Full time @GSK in Life Sciences
  • Cambridge, Massachusetts, United States View on Map
  • Post Date : January 23, 2024
  • Apply Before : March 1, 2024
  • View(s) 71

Job Detail

  • Job ID 89138
  • Job Type Full-time
  • Experience 5 Years
  • Industry Life Science
  • Qualifications Ph.D.

Job Description

If you want to be part of a collaborative and focused team with a mission to build GSK’s new therapeutic oligo platform, please apply!  We’re seeking an experienced Head of Platform Biology to join the RNA therapeutic team within GSK’s Medicines Design.

The successful candidate will build GSK’s therapeutic oligo biology capability and lead its implementation to deliver on GSK’s therapeutic oligo portfolio. You will be responsible for establishing the technologies required to identify, characterize and optimize compounds in drug discovery programs along with the infrastructure, and internal expertise necessary to realize GSK’s future RNA therapeutic ambitions. This role requires in-depth knowledge of RNA therapeutic drug development methods from Target Validation to Candidate Selection.

Key Responsibilities:

The responsibilities for this role are the following:

  • Lead the identification and mechanistic profiling and optimization of lead oligonucleotide compounds.
  • Support portfolio projects throughout lead discovery to candidate selection.  Work with teams to identify core risks to the delivery of an therapeutic oligo asset and assist with mitigation planning.
  • Represent RNA therapeutics as a technical/scientific lead on cross-functional research teams that include discovery and development organizations.
  • Drive the evaluation of external and internal capabilities and facilitate collaborations with external partners.
  • Work with subject matter experts to develop a plan to deliver on the medicine vision.
  • Contribute to the decision / inflection points that enable data driven project decision-making.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • A PhD in life sciences or related field with at least five years of experience in RNA drug discovery within or intersecting with the pharmaceutical or biotech industry.
  • Experience working with RNA biology and function.
  • Experience with identifying oligonucleotides that modulate RNA function (splicing, editing, silencing).
  • Experience with assay development and screening technologies.
  • People leadership experience managing large teams, including training, developing, and managing talent.

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

  • Expertise in RNA therapeutic drug development process.
  • Experience with high content screening technologies (i.e. RNAseq, imaging)
  • Knowledge and application of automation technologies.
  • Ability to work in a matrix team of multi-discipline experts including biology, chemistry, safety assessment, computational sciences, clinical scientists, translational scientists, and others.
  • First-hand experience of all phases of early drug discovery from target validation to candidate selection.
  • Understands the entirety of R&D across discovery and development.
  • Demonstrated effective communication and negotiation skills for a wide variety of audiences, including laboratory analysts and senior management.
  • Proven ability to build, motivate and inspire high performing teams, as well as effectively collaborate with cross-functional teams.
  • Demonstrated effective organizational skills, including ability to set, prioritize and achieve research goals.

Required skills

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