Making medicines out of pre-mRNA splicing modulators
April 29, 2021
Splicing is the process that edits precursor-messenger RNA (pre-mRNA) to generate the messenger RNA (mRNA) that carries the code from the nucleus to the cytoplasm where the ribosomes will translate it into a protein. The splicing reaction is carried out by a multi-ribonucleoprotein complex that excises the introns (non-coding regions) out from the pre-mRNA and joins the exons (coding regions) together to form the mRNA.