Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging
Mazur C, Powers B, Zasadny K, Sullivan JM, Dimant H, Kamme F, Hesterman J, Matson J, Oestergaard M, Seaman M, Holt RW, Qutaish M, Polyak I, Coelho R, Gottumukkala V, Gaut CM, Berridge M, Albargothy NJ, Kelly L, Carare RO, Hoppin J, Kordasiewicz H, Swayze ...
Plasma and Liver Protein Binding of N-Acetylgalactosamine-Conjugated Small Interfering RNA
Humphreys SC, Thayer MB, Lade JM, Wu B, Sham K, Basiri B, Hao Y, Huang X, Smith R, Rock BM. Drug Metab Dispos. 2019 Oct;47(10):1174-1182. PubMed
Nuclear and Cytoplasmatic Quantification of Unconjugated, Label-Free Locked Nucleic Acid Oligonucleotides
Pendergraff H, Schmidt S, Vikeså J, Weile C, Øverup C, Lindholm MW, Koch T. Nucleic Acid Ther. 2019 Oct 16. PubMed
Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease
Lee EC, Valencia T, Allerson C, Schairer A, Flaten A, Yheskel M, Kersjes K, Li J, Gatto S, Takhar M, Lockton S, Pavlicek A, Kim M, Chu T, Soriano R, Davis S, Androsavich JR, Sarwary S, Owen T, Kaplan J, Liu K, Jang G, Neben ...
The Pharmacokinetics of 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy
Bosgra S, Sipkens J, de Kimpe S, den Besten C, Datson N, van Deutekom J. Nucleic Acid Ther. 2019 Aug 20. PubMed
Metabolism and Disposition of Volanesorsen, a 2′ MOE Antisense Oligonucleotide, Across Species
Post N, Yu R, Greenlee S, Gaus H, Hurh E, Matson J, Wang Y. Drug Metab Dispos. 2019 Jul 26. PubMed
Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc3-Conjugated Antisense Oligonucleotides
Wang Y, Yu RZ, Henry S, Geary RS. Expert Opin Drug Metab Toxicol. 2019 Jun;15(6):475-485. PubMed
MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs
Gabisonia K, Prosdocimo G, Aquaro GD, Carlucci L, Zentilin L, Secco I, Ali H, Braga L, Gorgodze N, Bernini F, Burchielli S, Collesi C, Zandonà L, Sinagra G, Piacenti M, Zacchigna S, Bussani R, Recchia FA, Giacca M. Nature. 2019 May 8. PubMed
Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels
Nimjee SM, Dornbos D 3rd, Pitoc GA, Wheeler DG, Layzer JM, Venetos N, Huttinger A, Talentino SE, Musgrave NJ, Moody H, Rempel RE, Jones C, Carlisle K, Wilson J, Bratton C, Joseph ME, Khan S, Hoffman MR, Sommerville L, Becker RC, Zweier JL, Sullenger BA. ...
Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers
Moreno A, Pitoc GA, Ganson NJ, Layzer JM, Hershfield MS, Tarantal AF, Sullenger BA. Cell Chem Biol. 2019 Feb 15. pii: S2451-9456(19)30035-2. PubMed
