Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery
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Polymer-Mediated Inhibition of Pro-invasive Nucleic Acid DAMPs and Microvesicles Limits Pancreatic Cancer Metastasis
Naqvi I, Gunaratne R, McDade JE, Moreno A, Rempel RE, Rouse DC, Herrera SG, Pisetsky DS, Lee J, White RR, Sullenger BA. Mol Ther. 2018 Apr 4;26(4):1020-1031. PubMed
Chronic Toxicity Assessment of 2′-O-Methoxyethyl Antisense Oligonucleotides in Mice
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Intracerebroventricular Administration of a 2′-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain
Toonen LJA, Casaca-Carreira J, Pellisé-Tintoré M, Mei H, Temel Y, Jahanshahi A, van Roon-Mom WMC. Nucleic Acid Ther. 2018 Apr;28(2):63-73. PubMed
Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy
Komaki H, Nagata T, Saito T, Masuda S, Takeshita E, Sasaki M, Tachimori H, Nakamura H, Aoki Y, Takeda S. Sci Transl Med. 2018 Apr 18;10(437). PubMed
Systematic Analysis of Splice-Site-Creating Mutations in Cancer
Jayasinghe RG, Cao S, Gao Q, Wendl MC, Vo NS, Reynolds SM, Zhao Y, Climente-GonzĂ¡lez H, Chai S, Wang F, Varghese R, Huang M, Liang WW, Wyczalkowski MA, Sengupta S, Li Z, Payne SH, Fenyö D, Miner JH, Walter MJ; Cancer Genome Atlas Research Network, ...
Evolution of sequence-defined highly functionalized nucleic acid polymers
Chen Z, Lichtor PA, Berliner AP, Chen JC, Liu DR. Nat Chem. 2018 Apr;10(4):420-427. PubMed
Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor
Gaus H, Miller CM, Seth PP, Harris EN. Biochemistry. 2018 Apr 10;57(14):2061-2064. PubMed
saRNAdb: Resource of small activating RNAs for up-regulating the gene expression
Dar SA, Kumar M. J Mol Biol. 2018 Apr 3. pii: S0022-2836(18)30172-4. PubMed
Estimated number of off-target candidate sites for antisense oligonucleotides in human mRNA sequences
Yoshida T, Naito Y, Sasaki K, Uchida E, Sato Y, Naito M, Kawanishi T, Obika S, Inoue T. Genes Cells. 2018 Apr 18. PubMed