Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis

October 31st, 2018|Categories: Ago/siRNA/saRNA, Alternative splicing, Antisense/RNase H, Immune Stimulation, MicroRNA, Other papers of interest|

Järver P, Dondalska A, Poux C, Sandberg A, Bergenstråhle J, Sköld AE, Dereuddre-Bosquet N, Martinon F, Pålsson S, Zaghloul E, Brodin D, Sander B, Lennox KA, Behlke MA, El-Andaloussi S, Lehtiö J, Lundeberg J, LeGrand R, Spetz AL. Sci Rep. 2018 Oct 26;8(1):15841. PubMed

Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1

October 31st, 2018|Categories: Antisense/RNase H, Other papers of interest|

Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG. PLoS Genet. 2018 Oct 29;14(10):e1007732. PubMed

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