RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade
Ganesh S, Shui X, Craig KP, Park J, Wang W, Brown BD, Abrams MT. Mol Ther. 2018 Nov 7;26(11):2567-2579 PubMed
Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver
Otano I, Escors D, Schurich A, Singh H, Robertson F, Davidson BR, Fusai G, Vargas FA, Tan ZMD, Aw JYJ, Hansi N, Kennedy PTF, Xue SA, Stauss HJ, Bertoletti A, Pavesi A, Maini MK. Mol Ther. 2018 Nov 7;26(11):2553-2566. PubMed
RNAi modulation of placental sFLT1 for the treatment of preeclampsia
Turanov AA, Lo A, Hassler MR, Makris A, Ashar-Patel A, Alterman JF, Coles AH, Haraszti RA, Roux L, Godinho BMDC, Echeverria D, Pears S, Iliopoulos J, Shanmugalingam R, Ogle R, Zsengeller ZK, Hennessy A, Karumanchi SA, Moore MJ, Khvorova A. Nat Biotechnol. 2018 Nov 19. ...
An Investigational RNAi Therapeutic Targeting Factor XII (ALN-F12) for the Treatment of Hereditary Angioedema
Liu J, Qin J, Borodovsky A, Racie T, Castoreno A, Schlegel M, Maier M, Zimmerman T, Fitzgerald K, Butler J, Akinc A. RNA. 2018 Nov 21. PubMed
Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy following Mechanical Unloading
Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang BT. Mol Ther. 2018 Nov 7;26(11):2669-2680. PubMed
Long Non-coding RNA GMAN, Upregulated in Gastric Cancer Tissues, is Associated with Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS
Zhuo W, Liu Y, Li S, Guo D, Sun Q, Jin J, Rao X, Li M, Sun M, Jiang M, Xu Y, Teng L, Jin Y, Si J, Liu W, Kang Y, Zhou T. Gastroenterology. 2018 Nov 13. pii: S0016-5085(18)35268-5. PubMed
Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease
Long JM, Maloney B, Rogers JT, Lahiri DK. Mol Psychiatry. 2018 Nov 23. PubMed
Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells
Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CM, Goronzy JJ. Cell Rep. 2018 Nov 20;25(8):2148-2162.e5. PubMed
Inhibition of profibrotic microRNA-21 affects platelets and their releasate
Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, FernĂ¡ndez-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl ...
MicroRNA-182 Alleviates Neuropathic Pain by Regulating Nav1.7 Following Spared Nerve Injury in Rats
Cai W, Zhao Q, Shao J, Zhang J, Li L, Ren X, Su S, Bai Q, Li M, Chen X, Wang J, Cao J, Zang W. Sci Rep. 2018 Nov 13;8(1):16750. PubMed