Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice
Chappell AE, Gaus HJ, Berdeja A, Gupta R, Jo M, Prakash TP, Oestergaard M, Swayze EE, Seth PP. Nucleic Acids Res. 2020 Mar 17. PubMed
Delivery of Antisense Oligonucleotides to the Cornea
Chau VQ, Hu J, Gong X, Hulleman JD, Ufret-Vincenty RL, Rigo F, Prakash TP, Corey DR, Mootha VV. Nucleic Acid Ther. 2020 Mar 23. PubMed
Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs
Li Q, Chan C, Peterson N, Hanna RN, Alfaro A, Allen KL, Wu H, Dall'Acqua WF, Borrok MJ, Santos JL. ACS Chem Biol. 2020 Mar 13. PubMed
Aerosol Delivery of Synthetic mRNA to Vaginal Mucosa Leads to Durable Expression of Broadly Neutralizing Antibodies against HIV
Lindsay KE, Vanover D, Thoresen M, King H, Xiao P, Badial P, AraĂnga M, Park SB, Tiwari PM, Peck HE, Blanchard EL, Feugang JM, Olivier AK, Zurla C, Villinger F, Woolums AR, Santangelo PJ. Mol Ther. 2020 Mar 4;28(3):805-819. PubMed
Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia
Raal FJ, Kallend D, Ray KK, Turner T, Koenig W, Wright RS, Wijngaard PLJ, Curcio D, Jaros MJ, Leiter LA, Kastelein JJP; ORION-9 Investigators. N Engl J Med. 2020 Mar 18. PubMed
Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol
Ray KK, Wright RS, Kallend D, Koenig W, Leiter LA, Raal FJ, Bisch JA, Richardson T, Jaros M, Wijngaard PLJ, Kastelein JJP; ORION-10 and ORION-11 Investigators. N Engl J Med. 2020 Mar 18. PubMed
Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy
Frank DE, Schnell FJ, Akana C, El-Husayni SH, Desjardins CA, Morgan J, Charleston JS, Sardone V, Domingos J, Dickson G, Straub V, Guglieri M, Mercuri E, Servais L, Muntoni F; SKIP-NMD Study Group. Neurology. 2020 Mar 5. PubMed
A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA
de Jong OG, Murphy DE, Mäger I, Willms E, Garcia-Guerra A, Gitz-Francois JJ, Lefferts J, Gupta D, Steenbeek SC, van Rheenen J, El Andaloussi S, Schiffelers RM, Wood MJA, Vader P. Nat Commun. 2020 Feb 28;11(1):1113. PubMed
Coronavirus Highlights Urgent Need for Science-Backed Research
News Release from Mary Ann Liebert, Inc. publishers Coronavirus Highlights Urgent Need for Science-Backed Research As an academic publisher, we publish many important resources relevant to COVID-19 such as Health Security, Viral Immunology, Telemedicine and e-Health, and Vector Borne and Zoonotic Diseases. We are keeping ...
Targeting the IL-17 Receptor Using Liposomal Spherical Nucleic Acids as Topical Therapy for Psoriasis
Liu H, Kang RS, Bagnowski K, Yu JM, Radecki S, Daniel WL, Anderson BR, Nallagatla S, Schook A, Agarwal R, Giljohann DA, Paller AS. J Invest Dermatol. 2020 Feb;140(2):435-444.e4. PubMed