Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output
Zhao Q, Liu J, Deng H, Ma R, Liao JY, Liang H, Hu J, Li J, Guo Z, Cai J, Xu X, Gao Z, Su S. Cell. 2020 Oct 1;183(1):76-93.e22. Pubmed
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
Anderson EJ, Rouphael NG, Widge AT, Jackson LA, Roberts PC, Makhene M, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ, McDermott AB, Flach B, Lin BC, Doria-Rose NA, O'Dell S, Schmidt SD, Corbett KS, Swanson PA 2nd, Padilla M, Neuzil KM, Bennett H, Leav B, ...
Less Is More: Novel Hepatocyte-Targeted siRNA Conjugates for Treatment of Liver-Related Disorders
Weingärtner A, Bethge L, Weiss L, Sternberger M, Lindholm MW. Mol Ther Nucleic Acids. 2020 Sep 4;21:242-250. Pubmed
Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine
Mikami A, Erande N, Matsuda S, Kel'in A, Woods LB, Chickering T, Pallan PS, Schlegel MK, Zlatev I, Egli M, Manoharan M. Nucleic Acids Res. 2020 Sep 29:gkaa750. Pubmed
Sensitive fluorescence detection of SARS-CoV-2 RNA in clinical samples via one-pot isothermal ligation and transcription
Woo CH, Jang S, Shin G, Jung GY, Lee JW. Nat Biomed Eng. 2020 Sep 18:1-12. doi: 10.1038/s41551-020-00617-5. Pubmed
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
Jones SK Jr, Hawkins JA, Johnson NV, Jung C, Hu K, Rybarski JR, Chen JS, Doudna JA, Press WH, Finkelstein IJ. Nat Biotechnol. 2020 Sep 7. doi: 10.1038/s41587-020-0646-5. Pubmed
Systematic in vitro profiling of off-target affinity, cleavage and efficiency for CRISPR enzymes
Zhang L, Rube HT, Vakulskas CA, Behlke MA, Bussemaker HJ, Pufall MA. Nucleic Acids Res. 2020 May 21;48(9):5037-5053. Pubmed
Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice
Korecka JA, Thomas R, Hinrich AJ, Moskites AM, Macbain ZK, Hallett PJ, Isacson O, Hastings ML. Mol Ther Nucleic Acids. 2020 Sep 4;21:623-635. Pubmed
QR-313, an antisense oligonucleotide, shows therapeutic efficacy for treatment of dominant and recessive dystrophic epidermolysis bullosa: a preclinical study
Bornert O, Hogervorst M, Nauroy P, Bischof J, Swildens J, Athanasiou I, Tufa SF, Keene DR, Kiritsi D, Hainzl S, Murauer EM, Marinkovich MP, Platenburg G, Hausser I, Wally V, Ritsema T, Koller U, Haisma EM, Nyström A. J Invest Dermatol. 2020 Sep 15:S0022-202X(20)32061-3. Pubmed ...
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
Geekiyanage H, Rayatpisheh S, Wohlschlegel JA, Brown R Jr, Ambros V. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24213-24223. Pubmed