Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis
Järver P, Dondalska A, Poux C, Sandberg A, Bergenstråhle J, Sköld AE, Dereuddre-Bosquet N, Martinon F, Pålsson S, Zaghloul E, Brodin D, Sander B, Lennox KA, Behlke MA, El-Andaloussi S, Lehtiö J, Lundeberg J, LeGrand R, Spetz AL. Sci Rep. 2018 Oct 26;8(1):15841. PubMed
Aptamer-field-effect transistors overcome Debye length limitations for small-molecule sensing
Nakatsuka N, Yang KA, Abendroth JM, Cheung KM, Xu X, Yang H, Zhao C, Zhu B, Rim YS, Yang Y, Weiss PS, Stojanović MN, Andrews AM. Science. 2018 Oct 19;362(6412):319-324. PubMed
Small-molecule-based regulation of RNA-delivered circuits in mammalian cells
Wagner TE, Becraft JR, Bodner K, Teague B, Zhang X, Woo A, Porter E, Alburquerque B, Dobosh B, Andries O, Sanders NN, Beal J, Densmore D, Kitada T, Weiss R. Nat Chem Biol. 2018 Nov;14(11):1043-1050. PubMed
CRISPR-induced exon skipping is dependent on premature termination codon mutations
Sui T, Song Y, Liu Z, Chen M, Deng J, Xu Y, Lai L, Li Z. Genome Biol. 2018 Oct 17;19(1):164. PubMed
Systemic messenger RNA as an etiological treatment for acute intermittent porphyria
Jiang L, Berraondo P, Jericó D, Guey LT, Sampedro A, Frassetto A, Benenato KE, Burke K, Santamaría E, Alegre M, Pejenaute Á, Kalariya M, Butcher W, Park JS, Zhu X, Sabnis S, Kumarasinghe ES, Salerno T, Kenney M, Lukacs CM, Ávila MA, Martini PGV, Fontanellas ...
Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
Veiga N, Goldsmith M, Granot Y, Rosenblum D, Dammes N, Kedmi R, Ramishetti S, Peer D. Nat Commun. 2018 Oct 29;9(1):4493. PubMed
Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1
Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG. PLoS Genet. 2018 Oct 29;14(10):e1007732. PubMed
COMRADES determines in vivo RNA structures and interactions
Ziv O, Gabryelska MM, Lun ATL, Gebert LFR, Sheu-Gruttadauria J, Meredith LW, Liu ZY, Kwok CK, Qin CF, MacRae IJ, Goodfellow I, Marioni JC, Kudla G, Miska EA. Nat Methods. 2018 Sep 10. PubMed
Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation
Onizuka K, Miyashita T, Chikuni T, Ozawa M, Abe H, Nagatsugi F. Nucleic Acids Res. 2018 Sep 28;46(17):8710-8719. PubMed
Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin
Didiot MC, Ferguson CM, Ly S, Coles AH, Smith AO, Bicknell AA, Hall LM, Sapp E, Echeverria D, Pai AA, DiFiglia M, Moore MJ, Hayward LJ, Aronin N, Khvorova A. Cell Rep. 2018 Sep 4;24(10):2553-2560.e5. PubMed