Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor
Lin CY, Crowley ST, Uchida S, Komaki Y, Kataoka K, Itaka K. Mol Ther Nucleic Acids. 2019 Jun 7;16:162-171. PubMed
A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
Kose N, Fox JM, Sapparapu G, Bombardi R, Tennekoon RN, de Silva AD, Elbashir SM, Theisen MA, Humphris-Narayanan E, Ciaramella G, Himansu S, Diamond MS, Crowe JE Jr. Sci Immunol. 2019 May 17;4(35). PubMed
A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA
Baiersdörfer M, Boros G, Muramatsu H, Mahiny A, Vlatkovic I, Sahin U, Karikó K. Mol Ther Nucleic Acids. 2019 Apr 15;15:26-35. PubMed
Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening
Orlandini von Niessen AG, Poleganov MA, Rechner C, Plaschke A, Kranz LM, Fesser S, Diken M, Löwer M, Vallazza B, Beissert T, Bukur V, Kuhn AN, Türeci Ö, Sahin U. Mol Ther. 2019 Apr 10;27(4):824-836. PubMed
Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates
Zhu X, Yin L, Theisen M, Zhuo J, Siddiqui S, Levy B, Presnyak V, Frassetto A, Milton J, Salerno T, Benenato KE, Milano J, Lynn A, Sabnis S, Burke K, Besin G, Lukacs CM, Guey LT, Finn PF, Martini PGV. Am J Hum Genet. 2019 ...
Proximity Ligation Assays for In Situ Detection of Innate Immune Activation: Focus on In Vitro-Transcribed mRNA
Blanchard EL, Loomis KH, Bhosle SM, Vanover D, Baumhof P, Pitard B, Zurla C, Santangelo PJ. Mol Ther Nucleic Acids. 2019 Mar 1;14:52-66. PubMed
Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes
Gan LM, Lagerström-Fermér M, Carlsson LG, Arfvidsson C, Egnell AC, Rudvik A, Kjaer M, Collén A, Thompson JD, Joyal J, Chialda L, Koernicke T, Fuhr R, Chien KR, Fritsche-Danielson R. Nat Commun. 2019 Feb 20;10(1):871. PubMed
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
Hassett KJ, Benenato KE, Jacquinet E, Lee A, Woods A, Yuzhakov O, Himansu S, Deterling J, Geilich BM, Ketova T, Mihai C, Lynn A, McFadyen I, Moore MJ, Senn JJ, Stanton MG, Almarsson Ö, Ciaramella G, Brito LA. Mol Ther Nucleic Acids. 2019 Feb 7;15:1-11. ...
