Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier
Marcos-Contreras OA, Greineder CF, Kiseleva RY, Parhiz H, Walsh LR, Zuluaga-Ramirez V, Myerson JW, Hood ED, Villa CH, Tombacz I, Pardi N, Seliga A, Mui BL, Tam YK, Glassman PM, Shuvaev VV, Nong J, Brenner JS, Khoshnejad M, Madden T, Weissmann D, Persidsky Y, Muzykantov ...
The Dynamics of Cytoplasmic mRNA Metabolism.
Eisen TJ, Eichhorn SW, Subtelny AO, Lin KS, McGeary SE, Gupta S, Bartel DP. Mol Cell. 2019 Dec 30. pii: S1097-2765(19)30896-2. PubMed
Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation.
Yang Z, Shi J, Xie J, Wang Y, Sun J, Liu T, Zhao Y, Zhao X, Wang X, Ma Y, Malkoc V, Chiang C, Deng W, Chen Y, Fu Y, Kwak KJ, Fan Y, Kang C, Yin C, Rhee J, Bertani P, Otero J, Lu ...
MicroRNAs Cause Accelerated Decay of Short-Tailed Target mRNAs.
Eisen TJ, Eichhorn SW, Subtelny AO, Bartel DP. Mol Cell. 2019 Dec 30. PubMed
mRNA structure regulates protein expression through changes in functional half-life.
Mauger DM, Cabral BJ, Presnyak V, Su SV, Reid DW, Goodman B, Link K, Khatwani N, Reynders J, Moore MJ, McFadyen IJ. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24075-24083. PubMed
Mild Innate Immune Activation Overrides Efficient Nanoparticle-Mediated RNA Delivery.
Lokugamage MP, Gan Z, Zurla C, Levin J, Islam FZ, Kalathoor S, Sato M, Sago CD, Santangelo PJ, Dahlman JE. Adv Mater. 2019 Nov 19:e1904905. PubMed
Endocytic Profiling of Cancer Cell Models Reveals Critical Factors Influencing LNP-Mediated mRNA Delivery and Protein Expression.
Sayers EJ, Peel SE, Schantz A, England RM, Beano M, Bates SM, Desai AS, Puri S, Ashford MB, Jones AT. Mol Ther. 2019 Nov 6;27(11):1950-1962. PubMed
Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency
Truong B, Allegri G, Liu XB, Burke KE, Zhu X, Cederbaum SD, Häberle J, Martini PGV, Lipshutz GS. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21150-21159. PubMed
Pseudouridinylation of mRNA coding sequences alters translation
Eyler DE, Franco MK, Batool Z, Wu MZ, Dubuke ML, Dobosz-Bartoszek M, Jones JD, Polikanov YS, Roy B, Koutmou KS. Proc Natl Acad Sci U S A. 2019 Oct 31. PubMed
Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
Miao L, Li L, Huang Y, Delcassian D, Chahal J, Han J, Shi Y, Sadtler K, Gao W, Lin J, Doloff JC, Langer R, Anderson DG. Nat Biotechnol. 2019 Sep 30. PubMed