Rationally Designed Small Nucleic Acid-Based Inhibitors of CRISPR-Cas9
Barkau CL, O'Reilly D, Rohilla KJ, Damha MJ, Gagnon KT. Nucleic Acid Ther. 2019 Apr 16. PubMed
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
Grünewald J, Zhou R, Garcia SP, Iyer S, Lareau CA, Aryee MJ, Joung JK. Nature. 2019 Apr 17. PubMed
Precise therapeutic gene correction by a simple nuclease-induced double-stranded break
Iyer S, Suresh S, Guo D, Daman K, Chen JCJ, Liu P, Zieger M, Luk K, Roscoe BP, Mueller C, King OD, Emerson CP Jr, Wolfe SA. Nature. 2019 Apr;568(7753):561-565. PubMed
Development and Application of Base Editors
Yang B, Yang L, Chen J. CRISPR J. 2019 Apr;2:91-104. PubMed
Genome-wide target specificity of CRISPR RNA-guided adenine base editors
Kim D, Kim DE, Lee G, Cho SI, Kim JS. Nat Biotechnol. 2019 Mar 4. PubMed
In vivo RNA editing of point mutations via RNA-guided adenosine deaminases
Katrekar D, Chen G, Meluzzi D, Ganesh A, Worlikar A, Shih YR, Varghese S, Mali P. Nat Methods. 2019 Mar;16(3):239-242. PubMed
Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
Merkle T, Merz S, Reautschnig P, Blaha A, Li Q, Vogel P, Wettengel J, Li JB, Stafforst T. Nat Biotechnol. 2019 Jan 28. PubMed
Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity
O'Reilly D, Kartje ZJ, Ageely EA, Malek-Adamian E, Habibian M, Schofield A, Barkau CL, Rohilla KJ, DeRossett LB, Weigle AT, Damha MJ, Gagnon KT. Nucleic Acids Res. 2018 Dec 4. PubMed
Predictable and precise template-free CRISPR editing of pathogenic variants
Shen MW, Arbab M, Hsu JY, Worstell D, Culbertson SJ, Krabbe O, Cassa CA, Liu DR, Gifford DK, Sherwood RI. Nature. 2018 Nov;563(7733):646-651. PubMed
Synthetic Oligonucleotides Inhibit CRISPR-Cpf1-Mediated Genome Editing
Li B, Zeng C, Li W, Zhang X, Luo X, Zhao W, Zhang C, Dong Y. Cell Rep. 2018 Dec 18;25(12):3262-3272.e3. PubMed
