CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors
Lee C, Hyun Jo D, Hwang GH, Yu J, Kim JH, Park SE, Kim JS, Kim JH, Bae S. Mol Ther. 2019 Aug 7;27(8):1364-1371. PubMed
Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands
Lokugamage MP, Sago CD, Gan Z, Krupczak BR, Dahlman JE. Adv Mater. 2019 Aug 29:e1902251. PubMed
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease
Zeitler B, Froelich S, Marlen K, Shivak DA, Yu Q, Li D, Pearl JR, Miller JC, Zhang L, Paschon DE, Hinkley SJ, Ankoudinova I, Lam S, Guschin D, Kopan L, Cherone JM, Nguyen HB, Qiao G, Ataei Y, Mendel MC, Amora R, Surosky R, Laganiere ...
Enhancing gene editing specificity by attenuating DNA cleavage kinetics
Miller JC, Patil DP, Xia DF, Paine CB, Fauser F, Richards HW, Shivak DA, Bendaña YR, Hinkley SJ, Scarlott NA, Lam SC, Reik A, Zhou Y, Paschon DE, Li P, Wangzor T, Lee G, Zhang L, Rebar EJ. Nat Biotechnol. 2019 Aug;37(8):945-952. PubMed
Programmable RNA-Guided RNA Effector Proteins Built from Human Parts
Rauch S, He E, Srienc M, Zhou H, Zhang Z, Dickinson BC. Cell. 2019 Jun 27;178(1):122-134.e12. PubMed
Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins
Hoffmann MD, Aschenbrenner S, Grosse S, Rapti K, Domenger C, Fakhiri J, Mastel M, Börner K, Eils R, Grimm D, Niopek D. Nucleic Acids Res. 2019 Apr 15. PubMed
Analysis and minimization of cellular RNA editing by DNA adenine base editors
Rees HA, Wilson C, Doman JL, Liu DR. Sci Adv. 2019 May 8;5(5):eaax5717. PubMed
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T. Nat Commun. 2019 May 9;10(1):2127. PubMed
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR. Nat Biotechnol. 2019 May 20. PubMed
Development of hRad51-Cas9 nickase fusions that mediate HDR without double-stranded breaks
Rees HA, Yeh WH, Liu DR. Nat Commun. 2019 May 17;10(1):2212. PubMed