Aptamers against mouse and human tumor-infiltrating myeloid cells as reagents for targeted chemotherapy
De La Fuente A, Zilio S, Caroli J, Van Simaeys D, Mazza EMC, Ince TA, Bronte V, Bicciato S, Weed DT, Serafini P. Sci Transl Med. 2020 Jun 17;12(548):eaav9760. Pubmed
Aptamer-mediated reversible transactivation of gene expression by light
Mayer G, Renzl C, Kakoti A. Angew Chem Int Ed Engl. 2020 Aug 31. Pubmed
Base editors for simultaneous introduction of C-to-T and A-to-G mutations.
Sakata RC, Ishiguro S, Mori H, Tanaka M, Tatsuno K, Ueda H, Yamamoto S, Seki M, Masuyama N, Nishida K, Nishimasu H, Arakawa K, Kondo A, Nureki O, Tomita M, Aburatani H, Yachie N. Nat Biotechnol. 2020 Jul;38(7):865-869. Pubmed
A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
Mok BY, de Moraes MH, Zeng J, Bosch DE, Kotrys AV, Raguram A, Hsu F, Radey MC, Peterson SB, Mootha VK, Mougous JD, Liu DR. Nature. 2020 Jul 8. doi: 10.1038/s41586-020-2477-4. Pubmed
A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing.
GrĂ¼newald J, Zhou R, Lareau CA, Garcia SP, Iyer S, Miller BR, Langner LM, Hsu JY, Aryee MJ, Joung JK. Nat Biotechnol. 2020 Jul;38(7):861-864. Pubmed
Dual base editor catalyzes both cytosine and adenine base conversions in human cells.
Zhang X, Zhu B, Chen L, Xie L, Yu W, Wang Y, Li L, Yin S, Yang L, Hu H, Han H, Li Y, Wang L, Chen G, Ma X, Geng H, Huang W, Pang X, Yang Z, Wu Y, Siwko S, Kurita R, Nakamura ...
Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
Wei T, Cheng Q, Min YL, Olson EN, Siegwart DJ. Nat Commun. 2020 Jun 26;11(1):3232. Pubmed
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness
Yeh WH, Shubina-Oleinik O, Levy JM, Pan B, Newby GA, Wornow M, Burt R, Chen JC, Holt JR, Liu DR. Sci Transl Med. 2020 Jun 3;12(546):eaay9101. Pubmed
A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects
Zuo E, Sun Y, Yuan T, He B, Zhou C, Ying W, Liu J, Wei W, Zeng R, Li Y, Yang H. Nat Methods. 2020 Jun;17(6):600-604. Pubmed
Aptamer-T Cell Targeted Therapy for Tumor Treatment Using Sugar Metabolism and Click Chemistry
Liu CG, Wang Y, Liu P, Yao QL, Zhou YY, Li CF, Zhao Q, Liu GH, Zhang XL. ACS Chem Biol. 2020 May 28. Pubmed