Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs

Gagnon KT, Corey DR. Nucleic Acid Ther. 2019 Mar 23. In addition to the widespread use of synthetic oligonucleotides to manipulate RNA levels in basic research, interest in oligonucleotide therapeutics has increased substantially due to the commercial success of recently approved nucleic acid drugs. In turn, this has led to an influx of scientists largely…