RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome

February 25th, 2019|Categories: Paper of the Month|

Urak KT, Blanco GN, Shubham S, Lin LH, Dassie JP, Thiel WH, Chen Y, Sonkar VK, Lei B, Murthy S, Gutierrez WR, Wilson ME, Stiber JA, Klesney-Tait J, Dayal S, Miller FJ Jr, Giangrande PH. Nat Commun. 2019 Jan 10;10(1):116. The three joint first authors: ...

Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass

December 3rd, 2018|Categories: Paper of the Month|

Gunaratne R, Kumar S, Frederiksen JW, Stayrook S, Lohrmann JL, Perry K, Bompiani KM, Chabata CV, Thalji NK, Ho MD, Arepally G, Camire RM, Krishnaswamy S, Sullenger BA. Nat Biotechnol. 2018 Aug;36(7):606-613. The two joint first authors: Ruwan Gunaratne Kumar Shekhar ...

Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice

September 27th, 2018|Categories: Paper of the Month|

Sinha R, Kim YJ, Nomakuchi T, Sahashi K, Hua Y, Rigo F, Bennett CF, Krainer AR. Nucleic Acids Res. 2018 Jun 1;46(10):4833-4844. The three joint first authors: Rahul Sinha Young Jin Kim Tomoki Nomakuchi Currently, the most successful oligonucleotide ...

Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer

August 6th, 2018|Categories: Paper of the Month|

Reebye V, Huang KW, Lin V, Jarvis S, Cutilas P, Dorman S, Ciriello S, Andrikakou P, Voutila J, Saetrom P, Mintz PJ, Reccia I, Rossi JJ, Huber H, Habib R, Kostomitsopoulos N, Blakey DC, Habib NA. Oncogene. 2018 Jun;37(24):3216-3228 Small activating RNAs (saRNA) are the ...

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

June 27th, 2018|Categories: Paper of the Month|

Finn JD, Smith AR, Patel MC, Shaw L, Youniss MR, van Heteren J, Dirstine T, Ciullo C, Lescarbeau R, Seitzer J, Shah RR, Shah A, Ling D, Growe J, Pink M, Rohde E, Wood KM, Salomon WE, Harrington WF, Dombrowski C, Strapps WR, Chang Y, ...

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