Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass

Gunaratne R, Kumar S, Frederiksen JW, Stayrook S, Lohrmann JL, Perry K, Bompiani KM, Chabata CV, Thalji NK, Ho MD, Arepally G, Camire RM, Krishnaswamy S, Sullenger BA. Nat Biotechnol. 2018 Aug;36(7):606-613. The two joint first authors: An effective and safer alternative to unfractionated heparin (UFH) for systemic anticoagulation is needed. The Krishnaswamy and Sullenger…

Guidelines for Experiments using Antisense Oligonucleotides and Double-Stranded RNAs

Presenter: David Corey PhD, University of Texas, USA Date: 6 December 2018 Description: After decades of research and development, synthetic nucleic acids are beginning to enjoy significant success in the clinic. Approved drugs have increased interest in the field and many basic research studies have focused on synthetic nucleic acids that are intended to control…

Pitfalls and problems of miRNA expression analysis

February 12, 2019

Prof. Michela Alessandra Denti is Principal Investigator of the Laboratory of RNA Biology and Biotechnology at the Centre for Integrative Biology of the University of Trento, Italy since 2008. Her laboratory has two main research interests: modulation of RNA splicing as a cure for inherited diseases and microRNAs as biomarkers of cancer, cardiac and neurodegenerative