March 21, 2019
CRISPR-based genome editing has emerged as an exciting technology for biomedical and therapeutic applications. Since 2015, a number of studies have explored the effects of chemically modifying the guide RNA components of CRISPR enzymes and the spectrum of modifications that are compatible.
ApoE attenuates unresolvable inflammation by complex formation with activated C1q …………… Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T,…
Long Non-coding RNA ECRAR Triggers Post-natal Myocardial Regeneration by Activating ERK1/2 Signaling …………… Chen Y, Li X, Li B, Wang H, Li M, Huang S, Sun Y, Chen G, Si X, Huang C, Liao W, Liao Y, Bin J. Mol Ther. 2019 Jan 2;27(1):29-45. PubMed 00
Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing …………… Butin-Israeli V, Bui TM, Wiesolek HL, Mascarenhas L, Lee JJ, Mehl LC, Knutson KR, Adam SA, Goldman RD, Beyder A, Wiesmuller L, Hanauer SB, Sumagin R. J Clin Invest. 2019 Jan 14. pii: 122085. PubMed 00