July 25, 2019
Currently, effective cell-targeted delivery tools for oligonucleotide therapeutics are limited. Aptamers that internalize into target cells have been shown to deliver a wide variety of nucleic acid therapeutics, from siRNAs (<15 kDa, 19-21 nt/strand) to large...
May 15, 2019
MicroRNAs (miRNAs) have emerged as powerful regulators of the genome and, through concerted efforts to identify their function and evaluate their ability to alter cell growth…
An HK2 antisense oligonucleotide induces synthetic lethality in HK1-HK2+ multiple myeloma …………… Xu S, Zhou T, Doh HM, Trinh KR, Catapang A, Lee JT, Braas D, Bayley NA, Yamada RE, Vasuthasawat A, Sasine JP, Timmerman JM, Larson SM, Kim Y, Macleod AR, Morrison SL, Herschman HR. Cancer Res. 2019 Mar 18. pii: canres.2799.2018. PubMed 00
Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines …………… Linnane E, Davey P, Zhang P, Puri S, Edbrooke M, Chiarparin E, Revenko AS, Macleod AR, Norman JC, Ross SJ. Nucleic Acids Res. 2019 Mar 30. PubMed 00