The roles of structural dynamics in the cellular functions of RNAs
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Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc3-Conjugated Antisense Oligonucleotides
Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc3-Conjugated Antisense Oligonucleotides …………… Wang Y, Yu RZ, Henry S, Geary RS. Expert Opin Drug Metab Toxicol. 2019 Jun;15(6):475-485. PubMed 00
Targeting Huntingtin Expression in Patients with Huntington’s Disease
Tabrizi SJ, Leavitt BR, Landwehrmeyer GB, Wild EJ, Saft C, Barker RA, Blair NF, Craufurd D, Priller J, Rickards H, Rosser A, Kordasiewicz HB, Czech C, Swayze EE, Norris DA, Baumann T, Gerlach I, Schobel SA, Paz E, Smith AV, Bennett CF, Lane RM. N Engl J Med. 2019 May 6 The success of nusinersen…
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index …………… Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST. Nat Biotechnol. 2019…