mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway …………… Liang XH, Nichols JG, Hsu CW, Vickers TA, Crooke ST. Nucleic Acids Res. 2019 Jun 5. PubMed 00
NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice …………… Torres-Benito L, Schneider S, Rombo R, Ling KK, Grysko V, Upadhyay A, Kononenko NL, Rigo F, Bennett CF, Wirth B. Am J Hum Genet. 2019 Jun 4. PubMed 00
Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen …………… Uijl E, Mirabito Colafella KM, Sun Y, Ren L, van Veghel R, Garrelds IM, de Vries R, Poglitsch M, Zlatev I, Kim JB, Hoorn EJ, Foster D, Danser AHJ. Hypertension. 2019 Jun;73(6):1249-1257. PubMed 00
Investigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis …………… Kusner LL, Yucius K, Sengupta M, Sprague AG, Desai D, Nguyen T, Charisse K, Kuchimanchi S, Kallanthottathil R, Fitzgerald K, Kaminski HJ, Borodovsky A. Mol Ther Methods Clin Dev. 2019 May 10;13:484-492. PubMed 00