Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice …………… Shemesh CS, Yu RZ, Gaus HJ, Seth PP, Swayze EE, Bennett FC, Geary RS, Henry SP, Wang Y. Nucleic Acid Ther. 2016 Aug;26(4):223-35. PubMed 00
Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells …………… Niemietz CJ, Sauer V, Stella J, Fleischhauer L, Chandhok G, Guttmann S, Avsar Y, Guo S, Ackermann EJ, Gollob J, Monia BP, Zibert A, Schmidt HH. PLoS One. 2016 Sep 1;11(9):e0161455. PubMed 00
A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron protein …………… Seo J, Singh NN, Ottesen EW, Lee BM, Singh RN. Sci Rep. 2016 Aug 2;6:30778. PubMed 00
Catherine McKeen, PhD Operations Director Link Technologies How did you become interested in the field of oligonucleotides? I have worked in the oligonucleotide sector since 1994. Initially I worked with Tom Brown in