Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation

Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation …………… Steinert H, Sochor F, Wacker A, Buck J, Helmling C, Hiller F, Keyhani S, Noeske J, Grimm S, Rudolph MM, Keller H, Mooney RA, Landick R, Suess B, Fürtig B, Wöhnert J, Schwalbe H. Elife. 2017 May 25;6. pii: e21297.…

Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2′-C,4′-C-ethyleneoxy-bridged thymidine derivatives

Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2′-C,4′-C-ethyleneoxy-bridged thymidine derivatives …………… Osawa T, Sawamura M, Wada F, Yamamoto T, Obika S, Hari Y. Org Biomol Chem. 2017 May 10;15(18):3955-3963. PubMed 00

Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver

Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver …………… Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, Bell M, Lima WF, Swayze EE, Seth PP. Nucleic Acid Ther. 2017 Apr 27. PubMed 00