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Taking oligonucleotide research to its full therapeutic potential

Author Archives: OTS

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  2. Article author OTS

Gapmer Antisense Oligonucleotides Suppress the Mutant Allele of COL6A3 and Restore Functional Protein in Ullrich Muscular Dystrophy

Antisense/RNase HBy OTSSeptember 30, 2017Leave a comment

Gapmer Antisense Oligonucleotides Suppress the Mutant Allele of COL6A3 and Restore Functional Protein in Ullrich Muscular Dystrophy …………… Marrosu E, Ala P, Muntoni F, Zhou H. Mol Ther Nucleic Acids. 2017 Sep 15;8:416-427. PubMed 00

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model

Antisense/RNase HBy OTSSeptember 30, 2017Leave a comment

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model …………… Zhao HT, John N, Delic V, Ikeda-Lee K, Kim A, Weihofen A, Swayze EE, Kordasiewicz HB, West AB, Volpicelli-Daley LA. Mol Ther Nucleic Acids. 2017 Sep 15;8:508-519. PubMed 00

Antisense Oligonucleotides Reduce RNA Foci in Spinocerebellar Ataxia 36 Patient iPSCs

Antisense/RNase HBy OTSSeptember 30, 2017Leave a comment

Antisense Oligonucleotides Reduce RNA Foci in Spinocerebellar Ataxia 36 Patient iPSCs …………… Matsuzono K, Imamura K, Murakami N, Tsukita K, Yamamoto T, Izumi Y, Kaji R, Ohta Y, Yamashita T, Abe K, Inoue H. Mol Ther Nucleic Acids. 2017 Sep 15;8:211-219. PubMed 00

An antisense oligonucleotide targeting TGF-β2 inhibits lung metastasis and induces CD86 expression in tumor-associated macrophages

Antisense/RNase HBy OTSSeptember 30, 2017Leave a comment

An antisense oligonucleotide targeting TGF-β2 inhibits lung metastasis and induces CD86 expression in tumor-associated macrophages …………… Huber-Ruano I, Raventós C, Cuartas I, Sánchez-Jaro C, Arias A, Parra JL, Wosikowski K, Janicot M, Seoane J. Ann Oncol. 2017 Sep 1;28(9):2278-2285. PubMed 00

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