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Taking oligonucleotide research to its full therapeutic potential

Author Archives: OTS

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  2. Article author OTS

Antisense oligonucleotides selectively suppress target RNA in nociceptive neurons of the pain system and can ameliorate mechanical pain

Antisense/RNase HBy OTSOctober 31, 2017Leave a comment

Antisense oligonucleotides selectively suppress target RNA in nociceptive neurons of the pain system and can ameliorate mechanical pain …………… Mohan A, Fitzsimmons B, Zhao HT, Jiang Y, Mazur C, Swayze EE, Kordasiewicz HB. Pain. 2017 Sep 30. PubMed 00

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides

Antisense/RNase HBy OTSOctober 31, 2017Leave a comment

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides …………… Bailey JK, Shen W, Liang XH, Crooke ST. Nucleic Acids Res. 2017 Oct 13;45(18):10649-10671. PubMed 00

Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemia with splice-switching antisense oligonucleotides

Antisense/RNase HBy OTSOctober 31, 2017Leave a comment

Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemia with splice-switching antisense oligonucleotides …………… Liu J, Bhadra M, Sinnakannu JR, Yue WL, Tan CW, Rigo F, Ong ST, Roca X. Oncotarget. 2017 Sep 6;8(44):77567-77585. PubMed 00

Influence of mismatched and bulged nucleotides on SNP-preferential RNase H cleavage of RNA-antisense gapmer heteroduplexes

Antisense/RNase HBy OTSOctober 31, 2017Leave a comment

Influence of mismatched and bulged nucleotides on SNP-preferential RNase H cleavage of RNA-antisense gapmer heteroduplexes …………… Magner D, Biala E, Lisowiec-Wachnicka J, Kierzek R. Sci Rep. 2017 Oct 2;7(1):12532. PubMed 00

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