Acute hepatotoxicity of 2′ fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

Acute hepatotoxicity of 2′ fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins …………… Shen W, De Hoyos CL, Sun H, Vickers TA, Liang XH, Crooke ST. Nucleic Acids Res. 2018 Jan 30. PubMed 00