Investigation into the mechanism(s) that leads to platelet decreases in cynomolgus monkeys during administration of ISIS-104838, a 2′-MOE-modified antisense oligonucleotide

Investigation into the mechanism(s) that leads to platelet decreases in cynomolgus monkeys during administration of ISIS-104838, a 2′-MOE-modified antisense oligonucleotide …………… Narayanan PK, Shen L, Curtis BR, Bourdon M, Nolan JP, Zhou F, Christian B, Gupta S, Schaubhut JL, Greenlee S, Hoffmaster C, Burel S, Witztum JL, Engelhardt JA, Henry SP. Toxicol Sci. 2018 May…