Antisense Oligonucleotides- Mechanisms of Action and Rational Design

Categories: Past WebinarsPublished On: November 19th, 2019

Post Views: 4,539

Webinars

mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo

OTS2024-09-20T02:42:14+00:00August 28th, 2024|

Sequence- and Structure-Dependent Cytotoxicity of Phosphorothioate and 2’-O-Methyl Modified Single-Stranded Oligonucleotides

OTS2024-08-30T15:58:39+00:00August 21st, 2024|

Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation

OTS2024-09-06T03:30:39+00:00July 25th, 2024|

A Nucleic Acid Approach to Antibody Therapeutics

OTS2024-09-06T03:30:14+00:00July 18th, 2024|

Presenter: Robert MacLeod (Ionis Pharmaceuticals)

Date: February 26, 2020

Recording of the webinar: Click play to view

Presenter Biography

Robert MacLeod (Ionis Pharmaceuticals)

Dr. MacLeod is currently the Vice President Oncology Research and Development, and Franchise Head at Ionis Pharmaceuticals and has contributed to the discovery and development of clinical drug candidates in the several therapeutic areas including, oncology, thrombosis, inflammatory and muscle diseases. Prior to joining Ionis Dr. MacLeod held positions at Takeda Pharmaceuticals and was a founding scientist of MethylGene Inc. (now Mirati Therapeutics), where he directed the efforts of multidisciplinary drug discovery teams that identified several novel experimental therapeutics. Dr. MacLeod obtained his undergraduate degree in Chemistry and Biochemistry from Concordia University in Montreal and his doctoral degree from McGill University.

References

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Crooke, S. (2007). Antisense drug technology. 2nd ed. Boca Raton: CRC Press.
In particular chapter 10:
Pharmacological Properties of 2-O-Methoxyethyl-Modified Oligonucleotides
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N Engl J Med. 2015 Jan 15;372(3):232-40.
Targeting APOC3 in the familial chylomicronemia syndrome.
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AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer.
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Antisense Oligonucleotides- Mechanisms of Action and Rational Design

Webinars

mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo

Sequence- and Structure-Dependent Cytotoxicity of Phosphorothioate and 2’-O-Methyl Modified Single-Stranded Oligonucleotides

Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation

A Nucleic Acid Approach to Antibody Therapeutics

Presenter: Robert MacLeod (Ionis Pharmaceuticals)

Date: February 26, 2020

Recording of the webinar: Click play to view

Presenter Biography

Robert MacLeod (Ionis Pharmaceuticals)

References

Learn more

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Resources

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Antisense Oligonucleotides- Mechanisms of Action and Rational Design

Webinars

mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo

Sequence- and Structure-Dependent Cytotoxicity of Phosphorothioate and 2’-O-Methyl Modified Single-Stranded Oligonucleotides

Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation

A Nucleic Acid Approach to Antibody Therapeutics

Presenter: Robert MacLeod (Ionis Pharmaceuticals)

Date: February 26, 2020

Recording of the webinar: Click play to view

Presenter Biography

Robert MacLeod (Ionis Pharmaceuticals)

References

Learn more

Subscribe to our Newsletter

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