Categories: Past WebinarsPublished On: November 19th, 2019

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Webinars

Delivery of Chemically Stabilized RNAi molecules to the Central Nervous System

OTS2022-12-02T04:47:10+00:00October 21st, 2022|

An insider’s view into the preclinical development of an approved exon skipping drug

OTS2022-11-09T12:36:10+00:00October 21st, 2022|

Site-specific detection of mutagenic DNA damage with an artificial nucleotide

OTS2022-12-21T17:59:12+00:00October 21st, 2022|

Patient Advocacy and Therapeutic Development for Huntington’s Disease

OTS2022-10-28T11:47:02+00:00July 29th, 2022|

Antisense Oligonucleotides- Mechanisms of Action and Rational Design

Presenter: Robert MacLeod (Ionis Pharmaceuticals)

Date: February 26, 2020

Recording of the webinar: Click play to view

Presenter Biography

Robert MacLeod (Ionis Pharmaceuticals)

Dr. MacLeod is currently the Vice President Oncology Research and Development, and Franchise Head at Ionis Pharmaceuticals and has contributed to the discovery and development of clinical drug candidates in the several therapeutic areas including, oncology, thrombosis, inflammatory and muscle diseases. Prior to joining Ionis Dr. MacLeod held positions at Takeda Pharmaceuticals and was a founding scientist of MethylGene Inc. (now Mirati Therapeutics), where he directed the efforts of multidisciplinary drug discovery teams that identified several novel experimental therapeutics. Dr. MacLeod obtained his undergraduate degree in Chemistry and Biochemistry from Concordia University in Montreal and his doctoral degree from McGill University.

References

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Crystal structure and improved antisense properties of 2′-O-(2-methoxyethyl)-RNA.
Teplova M, Minasov G, Tereshko V, Inamati GB, Cook PD, Manoharan M, Egli M.
Nat Struct Biol. 1999 Jun;6(6):535-9.
Crooke, S. (2007). Antisense drug technology. 2nd ed. Boca Raton: CRC Press.
In particular chapter 10:
Pharmacological Properties of 2-O-Methoxyethyl-Modified Oligonucleotides
Frank Bennett
Factor XI antisense oligonucleotide for prevention of venous thrombosis.
Büller HR, Bethune C, Bhanot S, Gailani D, Monia BP, Raskob GE, Segers A, Verhamme P, Weitz JI; FXI-ASO TKA Investigators.
N Engl J Med. 2015 Jan 15;372(3):232-40.
Targeting APOC3 in the familial chylomicronemia syndrome.
Gaudet D, Brisson D, Tremblay K, Alexander VJ, Singleton W, Hughes SG, Geary RS, Baker BF, Graham MJ, Crooke RM, Witztum JL.
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Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study.
Finkel RS, Chiriboga CA, Vajsar J, Day JW, Montes J, De Vivo DC, Yamashita M, Rigo F, Hung G, Schneider E, Norris DA, Xia S, Bennett CF, Bishop KM.
Lancet. 2016 Dec 17;388(10063):3017-3026.
AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer.
Hong D, Kurzrock R, Kim Y, Woessner R, Younes A, Nemunaitis J, Fowler N, Zhou T, Schmidt J, Jo M, Lee SJ, Yamashita M, Hughes SG, Fayad L, Piha-Paul S, Nadella MV, Mohseni M, Lawson D, Reimer C, Blakey DC, Xiao X, Hsu J, Revenko A, Monia BP, MacLeod AR.
Sci Transl Med. 2015 Nov 18;7(314):314ra185.
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Antisense Oligonucleotides- Mechanisms of Action and Rational Design

Webinars

Delivery of Chemically Stabilized RNAi molecules to the Central Nervous System

An insider’s view into the preclinical development of an approved exon skipping drug

Site-specific detection of mutagenic DNA damage with an artificial nucleotide

Patient Advocacy and Therapeutic Development for Huntington’s Disease

Antisense Oligonucleotides- Mechanisms of Action and Rational Design

Presenter: Robert MacLeod (Ionis Pharmaceuticals)

Date: February 26, 2020

Recording of the webinar: Click play to view

Presenter Biography

Robert MacLeod (Ionis Pharmaceuticals)

References

Learn more

Subscribe to our Newsletter

Resources

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Search

Antisense Oligonucleotides- Mechanisms of Action and Rational Design

Webinars

Delivery of Chemically Stabilized RNAi molecules to the Central Nervous System

An insider’s view into the preclinical development of an approved exon skipping drug

Site-specific detection of mutagenic DNA damage with an artificial nucleotide

Patient Advocacy and Therapeutic Development for Huntington’s Disease

Antisense Oligonucleotides- Mechanisms of Action and Rational Design

Presenter: Robert MacLeod (Ionis Pharmaceuticals)

Date: February 26, 2020

Recording of the webinar: Click play to view

Presenter Biography

Robert MacLeod (Ionis Pharmaceuticals)

References

Learn more

Subscribe to our Newsletter

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