An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement
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Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties
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Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy
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Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease
Kumar P, Degaonkar R, Guenther DC, Abramov M, Schepers G, Capobianco M, Jiang Y, Harp J, Kaittanis C, Janas MM, Castoreno A, Zlatev I, Schlegel MK, Herdewijn P, Egli M, Manoharan M. Nucleic Acids Res. 2020 Mar 14. PubMed
U1 snRNP regulates chromatin retention of noncoding RNAs
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Endogenous MicroRNA Competition as a Mechanism of shRNA-Induced Cardiotoxicity
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Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping
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Aptamer-based optical manipulation of protein subcellular localization in cells
Xie S, Du Y, Zhang Y, Wang Z, Zhang D, He L, Qiu L, Jiang J, Tan W. Nat Commun. 2020 Mar 12;11(1):1347. PubMed
Bifunctional Aptamer-Doxorubicin Conjugate Crosses the Blood-Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells
Macdonald J, Denoyer D, Henri J, Jamieson A, Burvenich IJG, Pouliot N, Shigdar S. Nucleic Acid Ther. 2020 Apr;30(2):117-128. PubMed
Origins of the increased affinity of phosphorothioate-modified therapeutic nucleic acids for proteins
Hyjek-Składanowska M, Vickers T, Napiórkowska A, Anderson B, Tanowitz M, Crooke ST, Liang XH, Seth PP, Nowotny M. J Am Chem Soc. 2020 Mar 23. PubMed
