Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice
Klein AF, Varela MA, Arandel L, Holland A, Naouar N, Arzumanov A, Seoane D, Revillod L, Bassez G, Ferry A, Jauvin D, Gourdon G, Puymirat J, Gait MJ, Furling D, Wood MJA. J Clin Invest. 2019 Sep 3. PubMed
Immunogenicity and safety of a 2-dose hepatitis B vaccine, HBsAg/CpG 1018, in persons with diabetes mellitus aged 60-70 years
Hyer RN, Janssen RS. Vaccine. 2019 Sep 16;37(39):5854-5861. PubMed
Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
Miao L, Li L, Huang Y, Delcassian D, Chahal J, Han J, Shi Y, Sadtler K, Gao W, Lin J, Doloff JC, Langer R, Anderson DG. Nat Biotechnol. 2019 Sep 30. PubMed
Live imaging of mRNA using RNA-stabilized fluorogenic proteins
Wu J, Zaccara S, Khuperkar D, Kim H, Tanenbaum ME, Jaffrey SR. Nat Methods. 2019 Sep;16(9):862-865. PubMed
Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs
Chen X, Zhang D, Su N, Bao B, Xie X, Zuo F, Yang L, Wang H, Jiang L, Lin Q, Fang M, Li N, Hua X, Chen Z, Bao C, Xu J, Du W, Zhang L, Zhao Y, Zhu L, Loscalzo J, Yang Y. Nat ...
Lipid-based nanoparticle formulations for small molecules and RNA drugs
Ickenstein LM, Garidel P. Expert Opin Drug Deliv. 2019 Sep 17. PubMed
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system
Alterman JF, Godinho BMDC, Hassler MR, Ferguson CM, Echeverria D, Sapp E, Haraszti RA, Coles AH, Conroy F, Miller R, Roux L, Yan P, Knox EG, Turanov AA, King RM, Gernoux G, Mueller C, Gray-Edwards HL, Moser RP, Bishop NC, Jaber SM, Gounis MJ, ...
Quantification Methods for oligonucleotide therapeutics in serum and tissue
Presenter: Mai Thayer, Amgen, USA Date: October 8, 2019 Description: Oligonucleotides are a quickly evolving modality with strong proof of concept established in the clinic. Despite the clinical success of oligonucleotides, there is still limited understanding of ADME (absorption, disposition, metabolism and excretion) in ...
Interview with Jessica Rouge, PhD
Jessica Rouge, Ph.D., Assistant Professor Chemistry Department University of Connecticut How did you become interested in the field of oligonucleotides? One day I participated in a weekend biotechnology class at a community college that was designed for high school students where I ran a ...
Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease
Lee J, Pinares-Garcia P, Loke H, Ham S, Vilain E, Harley VR. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16577-16582. PubMed
