RNA Splicing by the Spliceosome.
Wilkinson ME, Charenton C, Nagai K. Annu Rev Biochem. 2019 Dec 3. PubMed
A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo.
Zhong G, Wang H, He W, Li Y, Mou H, Tickner ZJ, Tran MH, Ou T, Yin Y, Diao H, Farzan M. Nat Biotechnol. 2019 Dec 23. PubMed
mRNA structure regulates protein expression through changes in functional half-life.
Mauger DM, Cabral BJ, Presnyak V, Su SV, Reid DW, Goodman B, Link K, Khatwani N, Reynders J, Moore MJ, McFadyen IJ. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24075-24083. PubMed
HER3-targeted protein chimera forms endosomolytic capsomeres and self-assembles into stealth nucleocapsids for systemic tumor homing of RNA interference in vivo.
Alonso-Valenteen F, Pacheco S, Srinivas D, Rentsendorj A, Chu D, Lubow J, Sims J, Miao T, Mikhael S, Hwang JY, Abrol R, Medina Kauwe LK. Nucleic Acids Res. 2019 Dec 2;47(21):11020-11043. PubMed
Aptamers as Reversible Sorting Ligands for Preparation of Cells in Their Native State.
Gray BP, Requena MD, Nichols MD, Sullenger BA. Cell Chem Biol. 2019 Dec 21. pii: S2451-9456(19)30400-3. PubMed
Ligand Guided Selection (LIGS) with Artificially Expanded Genetic Information Systems against TCR-CD3ε.
Zumrut H, Yang Z, Williams N, Arizala JDR, Batool S, Benner S, Mallikaratchy P. Biochemistry. 2019 Dec 27. PubMed
Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides.
Scharner J, Ma WK, Zhang Q, Lin KT, Rigo F, Bennett CF, Krainer AR. Nucleic Acids Res. 2019 Dec 5. PubMed
Identifying and Avoiding tcDNA-ASO Sequence-Specific Toxicity for the Development of DMD Exon 51 Skipping Therapy.
Aupy P, EchevarrĂa L, Relizani K, Zarrouki F, Haeberli A, Komisarski M, Tensorer T, Jouvion G, Svinartchouk F, Garcia L, Goyenvalle A. Mol Ther Nucleic Acids. 2019 Nov 27;19:371-383. PubMed
Targeting Extracellular miR-21-TLR7 Signaling Provides Long-Lasting Analgesia in Osteoarthritis.
Hoshikawa N, Sakai A, Takai S, Suzuki H. Mol Ther Nucleic Acids. 2019 Nov 20;19:199-207. PubMed
A Sendai Virus-Based Cytoplasmic RNA Vector as a Novel Platform for Long-Term Expression of MicroRNAs.
Sano M, Nakasu A, Ohtaka M, Nakanishi M. Mol Ther Methods Clin Dev. 2019 Oct 31;15:371-382. PubMed