Patient Representative Webinar
Presenter: Daniel O’Reilly and Joseph Ochaba (Oligonucleotide Therapeutics Society) Date: November 19, 2019 Description: With a constantly growing list of oligonucleotide therapies that are entering the clinics, these exciting research molecules-turned-therapeutic strategy are starting to lead the way in treatments for many devastating diseases. ...
Dual Mechanisms of Action of Self-Delivering, Anti-HIV-1 FANA Oligonucleotides as a Potential New Approach to HIV Therapy
Takahashi M, Li H, Zhou J, Chomchan P, Aishwarya V, Damha MJ, Rossi JJ. Mol Ther Nucleic Acids. 2019 Sep 6; 17: 615–625 PubMed
Targeting castration-resistant prostate cancer with androgen receptor antisense oligonucleotide therapy
De Velasco MA, Kura Y, Sakai K, Hatanaka Y, Davies BR, Campbell H, Klein S, Kim Y, MacLeod AR, Sugimoto K, Yoshikawa K, Nishio K, Uemura H. JCI Insight. 2019 Sep 5;4(17). PubMed
Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1
Vickers TA, Rahdar M, Prakash TP, Crooke ST. Nucleic Acids Res. 2019 Sep 9. PubMed
Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor
Liu Y, Kanda A, Wu D, Ishizuka ET, Kase S, Noda K, Ichihara A, Ishida S. Mol Ther Nucleic Acids. 2019 Sep 6;17:113-125. PubMed
Targeted Delivery of C/EBPα-saRNA by RNA Aptamers Shows Anti-tumor Effects in a Mouse Model of Advanced PDAC
Yoon S, Huang KW, Andrikakou P, Vasconcelos D, Swiderski P, Reebye V, Sodergren M, Habib N, Rossi JJ. Mol Ther Nucleic Acids. 2019 Aug 22;18:142-154. PubMed
MicroRNA-221 Is Cardioprotective and Anti-fibrotic in a Rat Model of Myocardial Infarction
Zhou Y, Richards AM, Wang P. Mol Ther Nucleic Acids. 2019 Sep 6;17:185-197. PubMed
Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease
Lee EC, Valencia T, Allerson C, Schairer A, Flaten A, Yheskel M, Kersjes K, Li J, Gatto S, Takhar M, Lockton S, Pavlicek A, Kim M, Chu T, Soriano R, Davis S, Androsavich JR, Sarwary S, Owen T, Kaplan J, Liu K, Jang G, Neben ...
Combining Engineered U1 snRNA and Antisense Oligonucleotides to Improve the Treatment of a BBS1 Splice Site Mutation
Breuel S, Vorm M, Bräuer AU, Owczarek-Lipska M, Neidhardt J. Mol Ther Nucleic Acids. 2019 Aug 16;18:123-130. PubMed
Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide
Kourkouta E, Weij R, GonzĂ¡lez-Barriga A, Mulder M, Verheul R, Bosgra S, Groenendaal B, Puoliväli J, Toivanen J, van Deutekom JCT, Datson NA. Mol Ther Nucleic Acids. 2019 Sep 6;17:601-614. PubMed
