2017 OTS Lifetime Achievement Award Winner Mike Gait, Ph.D
Mike Gait, Ph.D Medical Research Council Michael J. Gait obtained a Ph. D. in 1973 in Chemistry from the University of Birmingham UK. From 1973-75 he was Research Associate at M.I.T with H. Gobind Khorana working one gene synthesis. Since 1975 he has been ...
OTS Launches Webinar Series
OTS is pleased to announce a new webinar series for 2018, bringing you hot topics in the field while giving participants a chance to interact with subject matter experts.
PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models
Zhao HT, Damle S, Ikeda-Lee K, Kuntz S, Li J, Mohan A, Kim A, Hung G, Scheideler MA, Scherer SS, Svaren J, Swayze EE, Kordasiewicz HB. J Clin Invest. 2018 Jan 2;128(1):359-368. PubMed
(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice from Diet-Induced Obesity and Hepatosteatosis
Ren L, Sun Y, Lu H, Ye D, Han L, Wang N, Daugherty A, Li F, Wang M, Su F, Tao W, Sun J, Zelcer N, Mullick AE, Danser AJ, Jiang Y, He Y, Ruan X, Lu X. Circ Res. 2018 Jan 4. PubMed
Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension
Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, RennĂ© T, Ruf W, MĂ¼nzel ...
Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations
Huang L, Low A, Damle SS, Keenan MM, Kuntz S, Murray SF, Monia BP, Guo S. Genome Biol. 2018 Jan 15;19(1):4. PubMed
Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat
Li L, Shen X, Liu Z, Norrbom M, Prakash TP, O'Reilly D, Sharma VK, Damha MJ, Watts JK, Rigo F, Corey DR. Nucleic Acid Ther. 2018 Jan 17. PubMed
Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice
Nuñez-DurĂ¡n E, Aghajan M, Amrutkar M, SĂ¼tt S, Cansby E, Booten SL, Watt A, StĂ¥hlman M, Stefan N, Häring HU, Staiger H, BorĂ©n J, Marschall HU, Mahlapuu M. Hepatol Commun. 2017 Nov 20;2(1):69-83. PubMed
Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery
Ma J, Kala S, Yung S, Chan TM, Cao Y, Jiang Y, Liu X, Giorgio S, Peng L, Wong AST. Mol Ther. 2018 Jan 3;26(1):70-83. PubMed
Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/β-catenin signaling pathway
Wang ZY, Hu M, Dai MH, Xiong J, Zhang S, Wu HJ, Zhang SS, Gong ZJ. Mol Cancer. 2018 Jan 8;17(1):3. PubMed