Novel DNA Aptamers Against CCL21 Protein: Characterization and Biomedical Applications for Targeted Drug Delivery to T Cell-Rich Zones
Chonco L, FernĂ¡ndez G, Kalhapure R, HernĂ¡iz MJ, GarcĂa-Oliva C, Gonzalez VM, MartĂn ME, Govender T, Parboosing R. Nucleic Acid Ther. 2018 May 7. PubMed
Degradation product characterization of therapeutic oligonucleotides using liquid chromatography mass spectrometry
Elzahar NM, Magdy N, El-Kosasy AM, Bartlett MG. Anal Bioanal Chem. 2018 May;410(14):3375-3384. PubMed
Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues
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Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA
Ball RL, Hajj KA, Vizelman J, Bajaj P, Whitehead KA. Nano Lett. 2018 May 8. PubMed
Intratumoral CpG-B promotes anti-tumoral neutrophil, cDC, and T cell cooperation without reprograming tolerogenic pDC
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Investigation into the mechanism(s) that leads to platelet decreases in cynomolgus monkeys during administration of ISIS-104838, a 2′-MOE-modified antisense oligonucleotide
Narayanan PK, Shen L, Curtis BR, Bourdon M, Nolan JP, Zhou F, Christian B, Gupta S, Schaubhut JL, Greenlee S, Hoffmaster C, Burel S, Witztum JL, Engelhardt JA, Henry SP. Toxicol Sci. 2018 May 29. PubMed
Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins: Pre-Specified Secondary End Points in ORION 1
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Eteplirsen treatment for Duchenne muscular dystrophy: Exon skipping and dystrophin production
Charleston JS, Schnell FJ, Dworzak J, Donoghue C, Lewis S, Chen L, Young GD, Milici AJ, Voss J, DeAlwis U, Wentworth B, Rodino-Klapac LR, Sahenk Z, Frank D, Mendell JR. Neurology. 2018 May 11. pii: 10.1212/WNL.0000000000005680. PubMed
Exploring PAZ/3′-overhang interaction to improve siRNA specificity. A combined experimental and modeling study
Alagia A, Jorge AF, AviĂ±Ă³ A, Cova TFGG, Crehuet R, Grijalvo S, Pais AACC, Eritja R. Chem Sci. 2018 Jan 15;9(8):2074-2086. PubMed
Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate
Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang QC, Wang HW. Cell. 2018 May 31;173(6):1549-1550. PubMed